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Assistant Project Scientist - Carrie Miceli Lab - UCLA MIMG
University of California Los Angeles
Details
Posted: 25-Nov-25
Location: Los Angeles, California
Type: Full-time
Internal Number: 6749579
University of California Los Angeles
Requisition Number: JPF10738
UCLA's Department of Microbiology, Immunology and Molecular Genetics is seeking to fill a full-time Assistant Project Scientist position in the lab of Professor Carrie Miceli. The Assistant Project Scientist candidate will perform research on Duchenne Muscular Dystrophy with an emphasis on immune mechanisms involved in driving fibrosis versus regeneration and identifying and targeting barriers limiting efficacy of dystrophin replacement therapies in a large collaborative team effort. The Assistant Project Scientist position is a 12-month non-Senate position.
Specific responsibilities for this position include but are not limited to:
- Process, bank and culture primary muscle biopsy samples and blood from DMD and healthy individuals, in some instances developing tissue culture-based models for in-culture investigations.
- Conduct research aimed understanding muscle remodeling in DMD muscle tissue before and after dystrophin replacement AAV gene therapy or other investigational treatments, including preparing samples for single cell/nuclei sequencing and coordinating sample tracking across group members for sequencing and interpretation.
- Design and carry out FACS based experiment aimed at characterizing primary or expanded and stimulated muscle mononuclear cells including fibroblast, satellite cell, lymphocytes, myeloid and endothelial cell populations.
- Use standard molecular techniques including western blot, RNA analysis, Elisa, DNA cloning/construction and immunohistochemistry to design and implement experiments to further probe/validate candidate mechanisms or drug targets identified.
- Perform myogenesis assays in coculture with other healthy or dystrophic cell types or drugs/inhibitors.
- T cell, macrophage, fibroblast bead purification and characterization, including characterization of cell populations using single cell transcriptomics.
- Work with core directors to implement and optimize application of core technologies to lab projects.
- Contribute to lab organization, cleanliness, equipment maintenance and stocking supplies.
- Assist with preparation of grant proposals.
- Preparation of manuscripts for publication in scientific journals.
Minimum Qualifications:
To apply, please visit: https://recruit.apo.ucla.edu/JPF10738
The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy, see: UC Nondiscrimination & Affirmative Action Policy, https://policy.ucop.edu/doc/4000376/DiscHarassAffirmAction
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UCLA is known worldwide for the breadth and quality of its academic, research, health care, cultural, continuing education and athletic programs. UCLA offers undergraduate degrees in more than 127 majors and graduate degrees in 198 program areas. UCLA has 11 highly regarded professional schools. Eight are ranked among the nation's top 15 in their field by U.S. News & World Report. UCLA is consistently among the most popular campus in the nation for undergraduate applicants. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to age, race, color, religion, sex, national origin, disability, or protected veteran status. Benefits:UCLA offers a comprehensive benefits package, including an average of three weeks' vacation per year; an average of 12 days per year sick leave; 13 paid holidays per year; health, dental and optical benefits; life insurance; disability insurance; the University of California Retirement Plan with 5 year vesting and various voluntary UC Savings Plans. There are also special programs and privileges available, such as accessibility to cultural and recreational programs, athletic events, and the University Credit Union.
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