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Posted: 13-Nov-25
Location: Cincinnati, Ohio
Internal Number: 100438-en_US
Current UC employees must apply internally via SuccessFactors
Next Lives at the University of Cincinnati
Founded in 1819, the University of Cincinnati ranks among the nation?s best urban public research universities. Home to more than 53,600 students, 12,000 faculty and staff, and over 360,000 living alumni, UC, a Carnegie 1 institution, combines research prowess with a physical setting The New York Times has called ?the most ambitious campus design program in the country." UC's momentum has never been stronger as the anchor of the Cincinnati Innovation District, the oldest cooperative education (co-op) program in the country with students earning $94 million annually through paid experiences, an academic health system, and as a member of the Big 12 Conference. The university contributes $10.6 billion in economic impact to the city and $22.7 billion to the state of Ohio. At UC, next is all of us. Learn more at uc.edu.
UC is a mission-driven organization where we are committed to student success and positively transforming the community through scholarship and service. We thrive on innovation, making an impact, and fostering an environment where staff and faculty are key contributors to UC?s success.
Job Overview
A full-time Postdoctoral Fellow position is available in the Structural Dynamics of Transcription Lab (PI: Dr. JB Rodriguez-Molina) in the Department of Molecular and Cellular Biosciences at the University of Cincinnati College of Medicine.
The Structural Dynamics of Transcription Lab investigates the molecular mechanisms of transcription termination and their regulation in health and disease, using an integrated structural biology workflow that combines biochemistry, genomics, and cryo-electron microscopy (cryo-EM). We are seeking a self-driven, ambitious, and creative scientist eager to explore fundamental questions in gene regulation and excited to work at the interface of structural biology, biochemistry, and functional genomics.
Depending on interests and expertise, the successful candidate may lead one of two complementary projects:
- A biochemical and structural project involving protein purification, reconstitution of macromolecular complexes, in vitro functional assays, and cryo-EM.
- A cellular and systems-level project focusing on CRISPR-based genetic screens, flow cytometry, genomics, and proteomics.
Both projects aim to uncover how transcription termination machinery integrates with broader regulatory networks and how its dysfunction contributes to disease. Candidates will have the opportunity to learn new techniques and contribute to an interdisciplinary, collaborative research environment. Training will be provided where needed. Our research is supported by state-of-the-art core facilities for cryo-EM, proteomics, genomics, and flow cytometry, as well as high-performance computing resources at the University of Cincinnati College of Medicine.
Essential Functions
- Drive the research project in collaboration with the PI and other team members.
- Design, execute, and analyze experiments; develop new approaches and hypotheses as appropriate.
- Prepare research summary reports, and present research findings in manuscripts, lab meetings, and scientific conferences.
- Contribute to grant proposals and collaborative efforts as opportunities arise.
- Stay abreast of developments in the field to maintain and enhance professional expertise.
- Mentor junior trainees and help maintain an open, supportive, and rigorous research environment.
- Play an active role in seeking career and research advice, both from the faculty supervisor and from other faculty members as well.
- Engage in professional development activities and career planning with mentorship from the PI.
- Contribute to lab maintenance, including equipment maintenance and ordering of supplies, as needed.
- Perform related duties based on departmental need. This job description can be changed at any time.
Required Education
Ph.D. (or equivalent) in Biochemistry, Molecular Biology, Genetics, Biophysics, or a related field.
Required Experience
- In-depth knowledge of specialized field, process or discipline.
- May require experience with specialized software programs.
At least three years of research experience in biochemistry, structural biology, molecular biology, or related disciplines.
Additional Qualifications Considered
Research experience in genetics, next generation sequencing, bioinformatics, biophysics, physics, math and engineering may also be considered.
Physical Requirements/Work Environment
- Office environment/no specific unusual physical or environmental demands.
Compensation and Benefits
UC offers an exceptional benefits package designed to support your well-being, financial security, and work-life balance. (UC Benefits Link) Highlights include:
Comprehensive Tuition Remission
UC provides tuition remission for you and your eligible dependents, covering tuition costs for nearly all undergraduate and graduate programs offered by the university.
Robust Retirement Plans
As a UC employee, you won?t contribute to Social Security (except Medicare). Instead, you?ll choose between state pension plans (OPERS, STRS) or an Alternative Retirement Plan (ARP), with UC contributing 14?18% of your salary based on position.
Real Work-Life Balance
UC prioritizes work-life balance with a generous time-off policy, including:
Vacation and sick time
11 paid holidays and additional end-of-year paid time off (Winter Season Days)
6 weeks of paid parental leave for new parents
Additional Benefits Include:
- Competitive salary based on experience
- Comprehensive health coverage (medical, dental, vision, prescription)
- Flexible spending accounts & wellness programs
- Professional development & mentorship opportunities
To learn more about why UC is a great place to work, please visit our careers page at https://www.uc.edu/careers.html
UC is an E-Verify employer. If hired into this position, you will be required to provide satisfactory proof of employment eligibility by providing acceptable, original forms of identification for employment verification via the Federal I-9 employment verification process. A list of acceptable documents can be seen here: https://www.uscis.gov/i-9-central/form-i-9-acceptable-documents
Important: To apply you must create a profile and submit a complete job application through the UC applicant portal. We are unable to consider ?easy apply? applications submitted via other websites. For questions about the UC recruiting process or to request accommodations with the application, please contact Human Resources at jobs@uc.edu.
Equal Opportunity Employer. Building a workplace where all qualified applicants will receive consideration for employment, including Individuals with Disabilities and Protected Veterans.
REQ: 100438
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