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Cancer Research Breakthroughs Begin with Employees Like You

The Merchant Laboratory is studying how tumor cells interact with their microenvironment and how this interaction contributes to the development and maintenance of cancer. In particular, the Merchant Lab is interested in how immune cells are trafficked into the tumor space and how immune cells can be harnessed to treat cancer.

Are you ready to apply your skills?

The Merchant lab is seeking a Research Bioinformatician I who can provide bioinformatics analysis of imaging mass cytometry (IMC). Our lab runs the imaging mass cytometry/CyTOF core facility at Cedars-Sinai. Imaging mass cytometry allows for highly multiplexed (35+ markers) imaging of immune and tumor cells, with spatial information and subcellular resolution. Imaging mass cytometry can be applied to all tissue types including cell lines, organoid, frozen section and FFPE fixed archival tissue. Experience with digital pathology, multiplex immunohistochemistry, CyCIF, image analysis, and/or GIS analysis would be highly preferred. Collaborations with other investigators at Cedars-Sinai allows access to data from single cell RNAseq, mass spec proteomics, and metabolic studies of immune cells. The goal is to generate publications and presentations that will advance the field of cancer immunology. Other opportunities to study computational and bioinformatic problems related to COVID-19 and T-cell receptor sequencing are available.

In addition, the Research Bioinformatician will be responsible for the following:

• Provides general bioinformatics analysis support for IMC projects, assist in development, testing and maintenance of software pipelines for IMC data analysis, statistical analysis, pathway analysis, and visualization.
• Summarizes data analyses results in the form of visualization plots & reports to aid in preliminary interpretations of the data.
• Software-engineering to improve usability, extensibility and scalability of existing programs including development of custom software interfaces & automation/optimization/parallelization of tasks.
• Helps to identify, evaluate, and incorporate relevant algorithms and software pipelines by reviewing pertinent literatures in bioinformatics and computational biology.
• Works with the PI and core collaborators on standard and complex research projects to customize analysis of data.
• Develop web-based custom analytics and data management applications and tools to facilitate large-scale data analysis.

• Working Title: Research Bioinformatician I
• Department: Home Dept - Hem - Onc
• Business Entity: Academic / Research
• City: Los Angeles
• Job Category: Academic/Research
• Job Specialty: Bioinformatics
• Position Type: Full-time
• Shift Length: 8 hour shift
• Shift Type: Day