Medical Laboratory Technologist / Scientist (Variant Curation)
Singapore General Hospital
Application
Details
Posted: 09-Dec-25
Location: Singapore, Singapore
Type: Contract
Categories:
Allied Health
Sector:
Hospital, Public and Private
Required Education:
Masters
Additional Information:
Employer will assist with relocation costs.
Internal Number: 70252
TRAIL (Translational Research and Innovation Lab) aims to bring precision medicine and genetics to the forefront of clinical care.
The Medical Laboratory Technologist / Scientist will be required to curate and maintain comprehensive genetic variant databases, ensuring the accuracy and clinical relevance of genomic information used in patient diagnosis and treatment. Working within our scientific team, you will analyse complex genetic data, interpret variant classifications, and collaborate with clinical geneticists and molecular scientists to support evidence-based genetic testing services.
This role requires expertise in genomic data analysis, literature review, and database management, as you'll be responsible for evaluating the clinical significance of genetic variants and maintaining up-to-date curation standards.
The roles and responsibilities will include (but not limited to) the following:
Perform genetic analysis and specialised investigations including variant calling, annotation, and clinical interpretation of genetic variants
Conduct bioinformatics analysis using established pipelines and software for next-generation sequencing data processing
Prepare comprehensive genetic reports with accurate variant classification according to established guidelines
Establish, implement and monitor quality control programs specific to genetic testing workflows
Assist in development and validation of genetic assays for translation into clinical use, including analytical validation studies
Assist in operation and maintenance of equipment used for genetic sequencing and analysis in the laboratory
Attend to laboratory service enquiries, providing accurate information about genetics test requirements, variant interpretation timelines, and procedures to healthcare professionals and clients
Provide support for collaborative research projects through active participation and literature search in genetics and variant interpretation
Maintain good records of all experimental data, variant databases, appropriate charts and tables for genetic analyses
Stay current with developments in genomic medicine, variant interpretation guidelines, and regulatory requirements
Knowledge of clinical genomics standards and guidelines for variant classification
Job Requirements:
Possessed a Master’s degree in Biomedical Science, Biological Science, Medical Technology, Genome Analytic or equivalent
Formal qualification (i.e., Fellowship in Genetic Pathology from the RCPA or AMP Molecular Genetic Pathology Review Course or equivalent) in molecular genetics, or related field with demonstrated competency in variant calling and reporting
Minimum 3 years of relevant job experience and demonstrated competency
Familiarity with Mendelian genetics and a thorough knowledge of molecular genetics
Experience with Genomics Viewer software, genomic data analysis software and variant interpretation databases
Singapore General Hospital, established in 1821, is the largest acute tertiary hospital in Singapore and ranked among the world’s best. It provides the most comprehensive patient-centred care with over 50 clinical specialties on its campus. As an Academic Medical Centre, it takes pride in training healthcare professionals and conducting cutting edge research to meet evolving needs of the nation as well as the region. Driven by a strong sense of purpose, SGH is committed to give its best to heal and bring hope, as it has for over 200 years.
A not-for-profit institution, SGH is wholly owned by the government of Singapore and the flagship hospital of the public healthcare system. SGH is a member of the SingHealth cluster of healthcare institutions.