Scheduled Hours

40

Position Summary

Assists in developing and conducting research projects, including experimental design, data analysis, and documentation of experiment results.

The bioinformatics position focuses on functional genomics using large next-generation sequencing datasets with an emphasis on Whole Genome Sequencing (WGS) and RNA-seq. The main interest of our laboratory is to understand the molecular mechanisms that control blood cancer development. Research opportunities are available for highly motivated individuals to study the role of mutations in genes and pre-mRNA splicing changes that control cell growth and blood cancer development. Research will include analysis of large whole genome sequencing data sets and RNA-seq data sets generated from various hematopoietic cell populations (including blood stem and progenitor cells) isolated from novel mutant mouse models and primary patient samples with blood cancers. All these studies involve state of the art technologies and incorporate bioinformatics, functional genomics, next-generation sequencing, hematopoiesis, stem cell, and tumor biology. Applicants should be proficient in python and R, knowledgeable in statistical modeling (in particular, generalized linear models) and experienced in whole genome sequencing, whole exome sequencing and RNA-seq analysis, including alignment, transcript assembly/quantification (e.g,kallisto), gene count quantification , differential gene expression (e.g., DESeq, edgeR), and differential splicing (e.g., DEXseq, rMATS). Pipeline development languages WDL,CWL, Nextflow. Experience in Google Cloud platform and AWS.

Job Description

• Independently develop a wide variety of computer programs to meet the needs of data collection, quality control, analysis and report generation.

• Lead and manage research projects and work together with junior members to complete data processing and analysis following specific timelines.

• Lead complex data analysis and writes interpretative reports for Principal investigators.

• Lead and collaborate within cross-functional teams.

• Lead analytical support for internal projects and external collaborations.

• Supervise database structure: includes updating, validating, curating and harmonizing longitudinal, cross-sectional data from different sources.

• Provide a centralized, confidential and secure access to phenotypic data to Principal investigators.

• Lead the response to data queries from Principal Investigators and external collaborators.

• Create reports and prepare highly technical presentations.

• Write manuscripts and communications for conference presentations.

• Present data in meetings and conferences.

• Other duties as assigned.

Working Conditions:
Job Location/Working Conditions

• Normal office environment

Physical Effort

• Typically sitting at a desk or table

Equipment

• Office equipment

The above statements are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all job duties performed by the personnel so classified. Management reserves the right to revise or amend duties at any time.

Required Qualifications

Education:

Bachelorâ™s degree or combination of education and/or experience may substitute for minimum education.

Certifications/Professional Licenses:

No specific certification/professional license is required for this position.

Work Experience:

Relevant Experience (12 Years)

Skills:

Not Applicable

Driver's License:

A driver's license is not required for this position.

More About This Job

Preferred Qualifications

• Strong background in PLINK, QC, IBD, PCA.
• Knowledge of association analyses, PRSice, MAGENTA, Mendelian Randomization, MANTRA, Coloc, QTL and Unix/Linux.

Preferred Qualifications

Education:

Master's degree, Ph.D. - Doctor of Philosophy

Certifications/Professional Licenses:

No additional certification/professional licenses unless stated elsewhere in the job posting.

Work Experience:

No additional work experience unless stated elsewhere in the job posting.

Skills:

Analytical Reasoning, Bioinformatics, Computational Structural Biology, Data Interpretations, Discrete Mathematics, Functional Genomics, Gene Expression Microarray, Genetic Studies, Java, Linux, Model Organism, Perl Programming, PLINK (Software), Principal Component Analysis (PCA), Probabilistic Modeling, Python (Programming Language), Quality Control Tools, R Programming, Scientific Programming Language, Scripting Languages, Statistical Analysis Software (SAS), Statistical Genetics, Statistics, Structured Query Language (SQL), Unix

Grade

R13

Salary Range

$72,900.00 - $132,200.00 / Annually

The salary range reflects base salaries paid for positions in a given job grade across the University. Individual rates within the range will be determined by factors including one's qualifications and performance, equity with others in the department, market rates for positions within the same grade and department budget.

Questions

For frequently asked questions about the application process, please refer to our External Applicant FAQ.

Accommodation

If you are unable to use our online application system and would like an accommodation, please email CandidateQuestions@wustl.edu or call the dedicated accommodation inquiry number at 314-935-1149 and leave a voicemail with the nature of your request.

All qualified individuals must be able to perform the essential functions of the position satisfactorily and, if requested, reasonable accommodations will be made to enable employees with disabilities to perform the essential functions of their job, absent undue hardship.

Pre-Employment Screening

All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.

Benefits Statement

Personal

• Up to 22 days of vacation, 10 recognized holidays, and sick time.

• Competitive health insurance packages with priority appointments and lower copays/coinsurance.

• Take advantage of our free Metro transit U-Pass for eligible employees.

• WashU provides eligible employees with a defined contribution (403(b)) Retirement Savings Plan, which combines employee contributions and university contributions starting at 7%.

Wellness

• Wellness challenges, annual health screenings, mental health resources, mindfulness programs and courses, employee assistance program (EAP), financial resources, access to dietitians, and more!

Family

• We offer 4 weeks of caregiver leave to bond with your new child. Family care resources are also available for your continued childcare needs. Need adult care? Weâ™ve got you covered.

• WashU covers the cost of tuition for you and your family, including dependent undergraduate-level college tuition up to 100% at WashU and 40% elsewhere after seven years with us.

For policies, detailed benefits, and eligibility, please visit: https://hr.wustl.edu/benefits/

EEO Statement

Washington University in St. Louis is committed to the principles and practices of equal employment opportunity and especially encourages applications by those from underrepresented groups. It is the Universityâ™s policy to provide equal opportunity and access to persons in all job titles without regard to race, ethnicity, color, national origin, age, religion, sex, sexual orientation, gender identity or expression, disability, protected veteran status, or genetic information.

Washington University is dedicated to building a community of individuals who are committed to contributing to an inclusive environment â“ fostering respect for all and welcoming individuals from diverse backgrounds, experiences and perspectives. Individuals with a commitment to these values are encouraged to apply.

Return to Search Results