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Details
Posted: 24-Apr-25
Location: Los Angeles, California
Type: Full-time
Internal Number: 6163432
University of California Los Angeles
Requisition Number: JPF10307
Job requirements
This position is intended for collaborative research working on X chromosome dosage compensation mechanisms in mouse and humans and the role of X-linked gene expression in the placenta. The Plath lab uses cutting-edge stem cell biology, mouse models, gene regulation, imaging, and omics techniques to study these questions.
The preferred qualifications for this position are as follows:
- Ph.D. in Gene Regulation, Biochemistry, Cell Biology, Developmental Biology, Stem Cell Biology, or a related field.
- At least 3 years of postdoctoral experience with a strong publication and collaborative record.
- Expertise in X-chromosome dosage compensation.
- Proficiency in molecular biology techniques, including RNA-seq, ATAC-seq, CRISPR-Cas9 genome editing, and advanced imaging.
- Experience in bioinformatics and analyzing single cell and bulk genomics dat.
- Strong organizational, problem-solving, and communication skills.
- Demonstrated ability to lead independent projects and work collaboratively within a team.
Job duties and responsibilities
- Design and conduct experiments to dissect molecular mechanisms underlying gene expression dosage compensation on the X chromosomes in placental mammals and apply genetic approaches to test functional relationships.
- Lead and execute projects focused on the understanding the role of X-linked genes expression in the placenta, at the feto-maternal interphase.
- Use state-of-the-art omics including genomics, metabolomics, proteomics and imaging techniques to characterize cell populations and lineage specification and their X-linked gene expression in vivo and in vitro.
- Utilize mouse models and human tissues in addressing questions of interest.
- Perform the analyses and interpretation of resulting genomics data.
- Develop and optimize protocols for the analysis of the mouse placenta by single cell and single nucleus genomics approaches.
- Collaborate with other lab members and external collaborators to integrate multi-disciplinary approaches into the studies of X-chromosome dosage compensation.
- Mentor junior scientists, postdocs, and students in experimental design, data analysis, and scientific writing.
- Contribute to the preparation of research manuscripts for publication, grant proposals, and progress reports and gather pilot data for grant proposals.
- Responsible for the maintenance of lab instruments and training new users in their operation. Help with safety protocols.
- Seek funds to establish own independence.
To apply, please visit: https://recruit.apo.ucla.edu/JPF10307
The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy, see: UC Nondiscrimination & Affirmative Action Policy, https://policy.ucop.edu/doc/4000376/DiscHarassAffirmAction
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UCLA is known worldwide for the breadth and quality of its academic, research, health care, cultural, continuing education and athletic programs. UCLA offers undergraduate degrees in more than 127 majors and graduate degrees in 198 program areas. UCLA has 11 highly regarded professional schools. Eight are ranked among the nation's top 15 in their field by U.S. News & World Report. UCLA is consistently among the most popular campus in the nation for undergraduate applicants. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to age, race, color, religion, sex, national origin, disability, or protected veteran status. Benefits:UCLA offers a comprehensive benefits package, including an average of three weeks' vacation per year; an average of 12 days per year sick leave; 13 paid holidays per year; health, dental and optical benefits; life insurance; disability insurance; the University of California Retirement Plan with 5 year vesting and various voluntary UC Savings Plans. There are also special programs and privileges available, such as accessibility to cultural and recreational programs, athletic events, and the University Credit Union.
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