We are seeking an enthusiastic and team-oriented individual who is passionate about science to join the Louissaint laboratory as a full-time research assistant. We are a translational lymphoma research laboratory that uses in-vitro and in-vivo patient-derived xenograft (PDX) models of B cell and T-cell lymphomas to make discoveries about lymphoma biology and to define new and effective lymphoma therapies.
Ongoing projects include:
Creation of the novel PDX models of ALK+ large B-cell lymphomas, plasmablastic lymphomas, and other aggressive lymphoma subtypes. Using our PDX models, we are defining the first effective and potentially curative therapies for these diseases. We are simultaneously studying mechanisms of resistance to these novel therapies.
We are using PDX models and organoid culture models of indolent but incurable follicular lymphoma to learn how these indolent B-cell lymphomas hijack the microenvironment to thrive and resist current therapies.
The candidate who joins our laboratory will have the opportunity work closely with Dr. Abner Louissaint, Jr. to help develop novel in-vitro and in-vivo models of lymphoma, and use these models to help define novel biological mechanisms, targets and game-changing therapeutics for clinically challenging lymphoma subtypes. We are looking for an individual who is self-motivated, a team player, and capable of handling multiple tasks and enjoys a fast-paced and collaborative research environment.
There is a strong emphasis on teamwork and positivity in our laboratory with regards to learning and troubleshooting new experimental techniques and assays. In addition, there is a strong commitment to career mentorship so that opportunities and experiences in the lab contribute significantly to each member's career goals. For these reasons, this position is well suited to those willing to commit a 2-3 year commitment in a challenging, yet rewarding experience in research.
PRINCIPAL DUTIES AND RESPONSIBILITIES:
The research assistant will be responsible for conducting experiments to advance research progress in the lab. As part of this work, the candidate who joins our laboratory will have the opportunity to gain extensive experience in the following research techniques and skills:
Mouse husbandry and drug administration (oral, intraperitoneal, venous)
In-vivo lymphoma monitoring in PDX mouse models (caliper measurements and performance of mouse ultrasound), and drug study design and analysis
Mouse necropsy and preparation of tissues for microscopic, flow cytometry, protein, and molecular genetic analysis
Multicolor flow cytometry
Nucleic acid extraction and PCR
For each of these skills, on the job training will be provided. Though not central to the envisioned research assistant role, there is also an opportunity to learn generation of in-vitro 3D organoid lymphomas modeling if there is interest.
The work will be performed in a fully equipped biological laboratory and in an associated mouse facility.
There are some core characteristics that are required for the Louissaint lab:
Attention to detail in completing tasks and a strong work ethic is essential.
Self-motivated, team player, and capable of multi-tasking
Desire to further develop communication skills in order to synthesize research findings for presentation in both oral and written formats.
Willingness to work closely with mice as described above
Previous experience with the following preferred but not required:
DNA / RNA extraction
Western blotting experience
The technician should have flexibility in their schedule to work on some evenings and weekends as needed to meet project goals.
We seek candidates who have at least 2 years of availability.
Bachelor's or Master's degree in Biology, Biochemistry, Chemistry, or a related field
At least 1 year minimum of previous molecular biology laboratory research experience
EEO Statement Massachusetts General Hospital is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. Applications from protected veterans and individuals with disabilities are strongly encouraged.Partner's Healthcare is acting as an Employment Agency in relation to this vacancy.
MGH Institute of Health Professions, founded by Massachusetts General Hospital in 1977, is an innovative and independent graduate school in Boston that is a member of Partners HealthCare. A progressive leader in developing comprehensive models of health care education, the MGH Institute prepares advanced practice professionals in the fields of nursing, physical therapy, occupational therapy and communication sciences and disorders through a distinctive combination of academic study, clinical practice, and research. More than 1,200 students are enrolled in graduate level and certificate programs, with an increasing number of courses available online. The Institute is accredited by the New England Association of Schools and Colleges (NEASC).