Single-cell Cancer Epigenetics and Bioinformatics. Postdoctoral positions are available in the laboratory of Yang E. Li (sites.wustl.edu/yelilab) in the Department of Neurological Surgery and Genetics, Washington University School of Medicine (WUSM). Our laboratory aims to develop innovative computational tools/methods and utilize single-cell (epi)genomic techniques to gain a comprehensive understanding of gene regulation in mammalian models and human diseases, particularly in brain tumors and neuropsychiatric disorders.
We aim to integrate single-cell multi-modal omics datasets to understand the epigenetic regulation in glioblastoma progression, and decipher the regulatory codes by developing interpretable deep learning models. Together, we can make a significant impact on the understanding of complex regulatory process and empower precision medicine of brain tumor and mental disorders.
Mapping the epigenetic landscapes in human brain tumors using single-cell multi-modal omics.
Characterizing epigenetic and transcriptomic heterogeneity in primary glioblastomas and in matched patient-derived models.
Deciphering the conservation of regulatory codes across species.
Developing computational tools/models and web portals.
Candidates must hold a Ph.D and/or M.D. degree (or anticipate receiving their degree in the near future) in Computational Biology, Bioinformatics, Cancer biology, or a related field.
Strong background and expertise in computational biology, with specific knowledge of deep learning and single-cell technologies.
Demonstrated ability to analyze large-scale biological datasets and apply statistical and machine learning techniques.
Excellent problem-solving and critical thinking skills.
Strong communication skills, with the ability to collaborate effectively within a multidisciplinary team.
Candidates with broad backgrounds in bioinformation/computational biology, genetics, evolutionary biology and cancer biology, are all welcome to apply.
Experience with popular deep learning frameworks (e.g., PyTorch, TensorFlow) and single-cell analysis tools (e.g., Seurat, Scanpy, SnapATAC) is highly desirable.
This position works in a laboratory environment with potential exposure to biological and chemical hazards.Â The individual must be physically able to wear protective equipment and to provide standard care to research animals.
Base pay is commensurate with experience.
Applicant Special Instructions
To apply, please submit the following documents to Yang E. Li, PhD at email@example.com:
Cover letter expressing your interest and highlighting your relevant experience.
Curriculum Vitae (CV) with a list of publications.
Contact information for at least two professional references.
If you are unable to use our online application system and would like an accommodation, please emailÂ CandidateQuestions@wustl.eduÂ or call the dedicated accommodation inquiry number at 314-935-1149 and leave a voicemail with the nature of your request.
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.
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