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Postdoctoral Research Fellow
Postdoctoral fellowships are available to study the molecular and cellular bases of neuronal dysfunction using the pediatric disorders, spinal muscular atrophy (SMA) and Glut1 deficiency syndrome (Glut1 DS) as disease paradigms. SMA is the most common genetic cause of childhood mortality. Glut1 DS is a significant cause of pediatric epilepsies. Current projects involve using model mice (J. Clin. Invest. 130: 1271; Neuron, 111: 1-17; J. Clin. Invest.124: 785; Nat. Commun. 8:14152) to 1) Define the cellular site(s) of action of the SMN and Glut1 proteins in causing neuronal degeneration, 2) Determine molecular pathways that link reduced SMN or Gl
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