Performs basic scientific research using a variety of techniques and approaches to gain a better understanding of neurological conditions using genetic mouse model systems. Cell culture and in vivo RNAi experience necessary.
Familiarity with all aspects of molecular cloning, including construction of prokaryotic and eukaryotic expression vectors, DNA sequencing, stable and transient transfection, gene expression assays (e.g. CAT, B-galactosidase, Luciferase assay, and GFP reporter systems). Southern and Northern blotting, site-directed mutagenesis, PCR based methods (including real time RT-PCR), RNase protection assay, in vitro transcription and translation, siRNA technology, microarray analysis, protein purification with affinity chromatography, and apoptosis assays (Hoechst stains, cell proliferation, etc.). Confocal microscopy will be utilized for colocalization studies of PrP with cellular organelles, as will immuno EM techniques. Protein expression, isolation, and detection, pulse-chase studies, cell fractionations, and other cell biological procedures should be mastered.
Supervises research technician(s) that provide general technical support for all members of the laboratory. Assists and provides technical and general scientific advice to other members of the laboratory.
Assists or leads in identifying and applying for sources of outside funding. Assists in preparing manuscripts and presentations at meetings.
Recognizes abnormal results and troubleshoots conditions or procedures to correct problems. Adapts existing procedures to current work needs and makes significant contributions to methodology. Summarizes results and assists in interpreting experimental findings.
Participates in the preparation and writing of grant applications and reports, and co-authors/authors scientific research manuscripts. Provides peer review of grant applications and scientific manuscripts.
Collaborates on development of new research projects with academic and community-based organizations.
May present work at scientific meetings.
Performs other related work as needed.
Doctoral level degree in neuroscience or related discipline.
Postdoctoral level research experience.
Broad knowledge in molecular and cell biological techniques, as well as experience in genetics, mouse models and histology; additional experience in RNAi techniques (in vitro and in vivo).
Demonstrated ability to publish first-author peer-reviewed papers.
Interact and communicate with clarity, tact, and courtesy with patrons, patients, staff, faculty, students, and others.
Attention to detail; maintain confidentiality.
Strong communication skills, verbal and written. Excellent interpersonal skills.
Strong data management skills and attention to detail.
Multi-task on multiple projects assign and prioritize.
Adaptability to changing working situations and work assignments.
Absorb large amounts of information quickly.
Cover Letter (preferred)
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