Career Center

Assistant Researcher Position In Quantitative Virology (Krogan lab at UCSF)

The lab of Professor Nevan Krogan in the Department of Cellular and Molecular Pharmacology (CMP) at the University of California, San Francisco is recruiting a full-time Assistant Researcher with expertise in quantitative virology, involving the application of hybrid computational and experimental systems biology approaches to studying viruses. This position will join the Host Pathogen Map Initiative (HPMI), a multi-disciplinary team of systems biologists and microbiologists. The HPMI group aims to comprehensively map and mechanistically study protein interaction networks, post-translational modifications, and gene expression changes that occur during infection, with the aim discovering novel antivirals.

The successful candidate will lead projects involved in integrating (1) virology, (2) computational modeling/bioinformatics, and (3) mass spectrometry proteomics. The candidate will study virus-host protein-protein interaction networks and their mechanistic relevance to the viral life cycle. Furthermore, the candidate will probe changes in post-translational modifications during infection, with a focus on phosphorylation and ubiquitination. In addition to an interest in performing wet-lab experiments, the candidate should also possess computational experience in R, Python, or similar. The candidate will be expected to perform routine bioinformatics analyses if the omics-level datasets as well as employ data integration strategies to extract biological and/or mechanistic hypotheses that can be subsequently tested in a wet-lab setting.

As an independent investigator, the candidate will: (1) perform proteomics experiments, (2) analyze proteomic data, (3) perform infection and mechanistic follow-up experiments with viruses, (4) perform bioinformatics/computational modeling using resulting omics-level datasets, (5) provide scientific oversight of the projects including review and advice on experimental design, data interpretation, and long-term planning to her or his team and colleagues; and (6) write manuscripts and applications for federally sponsored research.

Required Qualifications/Skills:
? PhD and/or MD degree or equivalent in systems biology, virology, biochemistry, chemistry, biomedical sciences, microbiology, or a related field.
? Extensive experience with techniques in molecular biology
? Experience in cell culture.
? Experience coding in R, Python, or similar and experience in bioinformatics.
? Experience in proteomic data analysis.
? Demonstrated experience as a research project lead.
? Experience managing collaborative projects between multiple laboratories.
? Demonstrated high productivity and successful record publishing in peer reviewed journals.
? Excellent oral and written communication skills.

Preferred Qualifications/Skills:
? Proteomics sample preparation.
? Mass spectrometry machine operation and maintenance.
? Experience in network modeling or mechanistic mathematical modeling.
? Multiscale data generation and analysis
? Data analysis using R
? Data visualization and analysis using Cytoscape
? Experience in writing and submitting sponsored research proposals
? Success in securing external research funding.
? Experience mentoring and advising students and trainees
? Community outreach

Please apply online at https://aprecruit.ucsf.edu/JPF03896 with a CV and the contact information of 1 reference. Candidates must meet required qualifications by time of hire. Candidate’s CV or cover letter must state basic qualifications, (or if pending).