Cold Spring Harbor Laboratory (CSHL) invites applications for a Postdoctoral Fellow position in the laboratory of Dr. Semir Beyaz. A successful candidate for this position will have completed PhD training in biomedical sciences, preferably in immunology, metabolism, cancer biology, epigenetics or microbiology. We are looking for an experienced and highly motivated scientist to join a collaborative team of scientists in our lab. The successful candidate will work on developing novel approaches to enhance the efficacy of immunotherapy in treatment resistant cancers by modulating nutrient metabolism. This exciting project is funded by a National Cancer Institute R37 MERIT Award (R37CA292807). In addition, the successful candidate will have the opportunity to work in collaboration with a leading US-based venture capital firm and biotech company for developing new skills on the process of translating discoveries from bench to bedside. 

The Beyaz lab aims to understand how nutrients and metabolism influence cellular networks that govern tissue regeneration, cancer and immunity. We dissect the precise mechanisms of how reciprocal interactions between tissue stem cells; immune cells and the microbiome affect tissue fitness or cancer outcomes. We utilize state-of-the-art experimental and computational approaches to integrate genetic, epigenetic, metabolism and microbiome data to identify causal targets that can be therapeutically exploited. To assess therapeutic potential of our discoveries, we have established a comprehensive and inclusive biobank with tissue specimens, autologous patient-derived organoids and immune cell co-culture systems from patients across diverse ancestries. The successful candidate will have access to all of these resources in the Beyaz lab and work in partnership with our clinical collaborators to develop highly effective cancer immunotherapy modalities with minimal toxicity to host.   

Education: PhD in biomedical sciences, ideally in immunology, metabolism, cancer biology, epigenetics or microbiology.

Skills and experience: The ideal candidate should have significant experience in molecular biology and mouse models of cancer. Having publications in the fields of metabolism, immunology, epigenetics or cancer therapeutics will be an advantage. 

How to Apply:

For immediate consideration please apply to the opening found here: Postdoctoral Fellow- Beyaz Lab  Position ID: 1839 In addition, candidates should e-mail their application to beyaz@cshl.edu as a single pdf file with subject: Research Investigator Application. The application file should include: (1) CV with the publication list, (2) a brief description of research interests, (3) contact information for three references. We look forward to your application!