The Embree's Laboratory at Columbia University, College of Dental Medicine is recruiting a talented and motivated Postdoctorate Scientist to advance our NIH-funded program in skeletal biology, osteoarthritis, and regenerative medicine.  Our group integrates mouse genetics, large-animal models, biomaterials, and sequencing approaches to uncover mechanisms of joint development and degeneration and to develop novel therapies.

Key Responsibilities

• Mouse genetics & model development: Design, generate, and characterize new transgenic and knockout mouse models to investigate stem/progenitor cell fate, cell niches, and osteoarthritis pathogenesis.
• Cell sequencing: Lead studies involving scRNA-seq, spatial transcriptomics, and multi-omics integration to define cell states in development and disease.
• Bioinformatics: Apply advanced computational tools to analyze sequencing datasets, identify molecular drivers of cell fate, and integrate data across species (mouse, rabbit, porcine, human).
• Experimental biology: Contribute to complementary in vitro and in vivo assays, including biomaterial/hydrogel fabrication, primary cell culture, biomechanical testing, and histological analyses.
• Maintain precise records (daily lab journals, animal logs) and ensure compliance with animal research standards.
• Actively engage in weekly lab meetings and one-on-one mentoring sessions with Dr. Mildred Embree.

• PhD (or equivalent) in genetics, bioinformatics, biomedical sciences, or related field.
• Proven expertise in mouse genetics (breeding, colony management, CRISPR/Cas9 or other engineering methods) and/or bioinformatics (R, Python, Seurat, Cell Ranger, or comparable platforms).
• Demonstrated track record with single-cell sequencing, spatial transcriptomics, or multi-omics pipelinesstrongly preferred.
• Strong organizational skills and ability to work both independently and collaboratively.

Qualified applicants should submit a CV along with a cover letter indicating career goals. 

Columbia University is an Equal Opportunity Employer / Disability / Veteran

Pay Transparency Disclosure

The salary of the finalist selected for this role will be set based on a variety of factors, including but not limited to departmental budgets, qualifications, experience, education, licenses, specialty, and training.  The above hiring range represents the University?s good faith and reasonable estimate of the range of possible compensation at the time of posting.

About Columbia University

Columbia University is one of the world's most important centers of research and at the same time a distinctive and distinguished learning environment for undergraduates and graduate students in many scholarly and professional fields. The University recognizes the importance of its location in New York City and seeks to link its research and teaching to the vast resources of a great metropolis. It seeks to attract a diverse and international faculty and student body, to support research and teaching on global issues, and to create academic relationships with many countries and regions. It expects all areas of the university to advance knowledge and learning at the highest level and to convey the products of its efforts to the world.

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