The Yang Lab is in the Columbia University Department of Molecular Pharmacology and Therapeutics and the Irving Cancer Center. The lab's primary focuses are on investigating tumor evolution and drug resistance mechanisms, and developing new molecular recording technologies. The lab employs multidisciplinary approaches to study cancer evolution, including developing CRISPR-based molecular recording tools to track tumor evolution history, modeling tumor progression using genetically engineered mouse models, applying single cell genomics tools to dissect tumor heterogeneity, and dissecting the molecular and cellular mechanisms of cancer evolution. Building upon the CRISPR-based molecular recording technology that Dr. Yang has developed, the lab will continue to integrate cancer biol