The Aguirre laboratory at Dana-Farber Cancer Institute and Harvard Medical School studies the genetics and biology of pancreatic cancer, one of the deadliest human cancer types. We utilize variety of molecular biology and genomic approaches to understand GI cancer with three major focus areas: 1) Discovery and validation of the new therapeutic targets in pancreatic cancer; 2) Investigating RAS biology and targeting in pancreatic cancer; and 3) Understanding the genetic and phenotypic subtypes of pancreatic cancer using single cell genomic and transcriptomic analysis of tumor biopsies and patient-derived organoid models. Research in the laboratory ranges from basic mechanistic investigation of cancer gene function or novel small molecule therapeutics to highly translational ge