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Posted: 03-Mar-25
Location: St. Louis, Missouri
Type: Full-time
Internal Number: JR87585
Position Summary
The Cruchaga Lab at WashU Medicine is recruiting multiple Postdoctoral Research Associates. The NeuroGenomics and Informatics Center generates and analyzes Whole-Genome Sequencing data and high-throughput, multi-dimensional -omic data to study neurodegeneration and diseases of the central nervous system, with an emphasis on Alzheimer disease, Parkinsonâ™s disease, and other dementias. The ultimate goal of the NGI is to understand the biology of these diseases, to define novel biomarkers, and to identify novel therapeutic targets. WashU Medicine is renowned for its research cohorts of neurodegenerative disorders, which include clinical, neuroimaging, and fluid biomarker phenotypes.Characterization of the genetic topography of Alzheimer's disease (AD) provides a unique opportunity to understand the disease. We are looking for investigators with expertise in Whole Genome and Exome data, colocalization, Mendelian Randomization, and TWAS/Fusion approaches to lead our effort to identify new genes involved in AD etiology.
Job Description
Primary Duties & Responsibilities:
Information on being a postdoc at Washington University in St. Louis can be found at https://postdoc.wustl.edu/prospective-postdocs-2/.
Recent publications on the subject:
- Fernandez et al., âœGenetic and multi-omic resources for Alzheimer disease and related dementia from the Knight Alzheimer Disease Research Centerâ, Sci Data. 2024 PMID: 38997326
- Cruchaga et al., âœNovel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracell signaling pathwaysâ, Res Sq, 2024. PMID: 38883718
- Wang et al., âœProteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer's diseaseâ, Mol Neurodegenr. 2024. PMID: 38172904
- Ray et al. âœThe Early-Onset Alzheimer's Disease Whole-Genome Sequencing Project: Study design and methodologyâ, Alzheimers Dement. 2023, PMID: 37390458
- Ali et al., âœLarge multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer diseaseâ, Acta Neuropathol Commun, 2023 PMID: 37101235
Working Conditions:
This position works in a laboratory environment with potential exposure to biological and chemical hazards. The individual must be physically able to wear protective equipment and to provide standard care to research animals.
Salary Range:
Base pay is commensurate with experience.
Diversity is a core value at Washington University School of Medicine and in the Department of Psychiatry. We are committed to building and sustaining inclusive and equitable working and learning environments for all students, staff, trainees, and faculty. We believe that building a diverse team enriches us individually and as a department by exposing us to a broad range of ways to understand and engage with the world, identify challenges, and to discover, design and deliver solutions. In order to achieve these objectives, candidates are expected to align with the school's mission of promoting inclusive excellence. They should be prepared to further this objective within Washington University and collaborate with diverse communities of students, faculty, staff, trainees, and patients. Visit our Websites to learn more about DEI initiatives in the Department of Psychiatry (https://psychiatry.wustl.edu/diversity-equity-inclusion-2/) and at WUSM (https://diversity.med.wustl.edu/).   Â
The above statements are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all job duties performed by the personnel so classified. Management reserves the right to revise or amend duties at any time.Required Qualifications
Education:
Ph.D., M.D. Or Equivalent Terminal Or Doctoral Degree.
Certifications:
Work Experience:
Skills:
Driver's License:
More About This Job
Required Qualifications:
- A PhD in Genetics, Bioinformatics, Computer Science, Data Science, Statistical Genomics, or a related discipline involving the interrogation of â˜omicsâ™ datasets, or expect to obtain a degree in the near future
- Hands-on experience using PLINK, SKAT, FUSION, BWA, and/or GATK with large-scale human genomic or other omics (preferably related to neurodegeneration) studies.
Preferred Qualifications:
- Experience performing colocalization, Mendelian randomization.
- Solid skills in at least one programming language (R, Python, or Perl) and experience working in Linux and/or high-performance cluster environments.
- A strong ability to perform analytical reasoning to extract biological insights from data-driven approaches.
- Familiarity with interrogation of publicly available resources (highly beneficial).
Preferred Qualifications
Education:
No additional education beyond what is stated in the Required Qualifications section.
Certifications:
Work Experience:
Skills:
Questions
For frequently asked questions about the application process, please refer to our External Applicant FAQ.
Accommodation
If you are unable to use our online application system and would like an accommodation, please email CandidateQuestions@wustl.edu or call the dedicated accommodation inquiry number at 314-935-1149 and leave a voicemail with the nature of your request.
All qualified individuals must be able to perform the essential functions of the position satisfactorily and, if requested, reasonable accommodations will be made to enable employees with disabilities to perform the essential functions of their job, absent undue hardship.Pre-Employment Screening
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.Benefits Statement
Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status, full-time equivalent (FTE) workload, and weekly standard hours. Please visit our website at https://hr.wustl.edu/benefits/ to view a summary of benefits.EEO/AA Statement
Washington University in St. Louis is committed to the principles and practices of equal employment opportunity and especially encourages applications by those from underrepresented groups. It is the Universityâ™s policy to provide equal opportunity and access to persons in all job titles without regard to race, ethnicity, color, national origin, age, religion, sex, sexual orientation, gender identity or expression, disability, protected veteran status, or genetic information.Diversity Statement
Washington University is dedicated to building a diverse community of individuals who are committed to contributing to an inclusive environment â“ fostering respect for all and welcoming individuals from diverse backgrounds, experiences and perspectives. Individuals with a commitment to these values are encouraged to apply.