Organization OverviewCells are constantly subjected to mechanical forces that originate either externally from the environment or internally from cellular machinery. Headed by Dr. Gregory M. Alushin, the Laboratory of Structural Biophysics and Mechanobiology studies how cells use changes in the conformation of actin filaments within their internal skeletons to sense and respond to those forces. Over the long term, the lab seeks to understand how changes to actin are linked to alterations in gene expression in development and disease. OverviewThe Alushin lab uses a combination of cell biology, biophysics, and cryo-electron microscopy (cryo-EM) structural biology to decipher how cells perceive mechanical forces through the cytoskeleton. We seek a R