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Cincinnati, Ohio
Posted: 26-Nov-24
Location: Cincinnati, Ohio
Internal Number: 97777-en_US
Current UC employees must apply internally via SuccessFactors
Founded in 1819, the University of Cincinnati ranks among the nation?s best urban public research universities. Home to 53,235 students, more than 11,000 faculty and staff and 350,000+ living alumni, UC combines a Top 35 public research university with a physical setting The New York Times calls ?the most ambitious campus design program in the country.?
With the launch of Next Lives Here, the Cincinnati Innovation District, a $100 million JobsOhio investment, three straight years of record enrollment, worldwide leadership in cooperative education, a dynamic academic health center and entry into the Big 12 Conference, UC?s momentum has never been stronger. UC?s annual budget stands at $1.85 billion, and its endowment totals nearly $1.8 billion.
Job Overview
As one of the oldest medical schools in the country, the University of Cincinnati College of Medicine (COM) has a reputation for training best-in-class health care professionals and developing cutting-edge procedures and research that improves the health and clinical care of patients. In partnership with the UC Health academic healthcare system and Cincinnati Children?s Hospital Medical Center, College of Medicine?s faculty are transforming the world of medicine every day. The Department of Internal Medicine is a top-tier department with world-renowned faculty and staff.
A full time Research Associate staff position is available in the laboratory of Dr. George Leikauf, Division of Pulmonary, Critical Care, and Sleep Medicine at the University of Cincinnati College of Medicine.
We are seeking a highly motivated Research Associate to join our dynamic research team focused on understanding the mechanisms underlying acute lung injury. This position is funded by a grant aimed at investigating the progression of lung injury caused by acrolein and phosgene inhalation and exploring potential therapeutic targets. The successful candidate will contribute to multi-omic analysis, in vivo studies, and molecular biology experiments to elucidate the mechanisms of lung injury and resolution.
This role offers the opportunity to work on cutting-edge research with the potential to make a significant impact in the field of pulmonary disease and toxicology. You will work in a collaborative environment with a team of experts, utilizing innovative techniques and state-of-the-art technologies. This is an excellent opportunity for someone looking to grow their research skills and contribute to the development of therapies for conditions with unmet clinical needs.
Essential Functions
- Conduct in vivo experiments using mouse models to investigate the progression of CIALI in response to acrolein and phosgene exposure, including administration of inhalants, bronchoalveolar lavage (BAL), and tissue collection.
- Contribute to multi-omic analyses, including spatial lipidomics, metabolomics, and transcriptomics, to assess the cellular and subcellular responses in lung tissue.
- Utilize single-cell RNA sequencing to analyze gene expression changes at the cellular level and assist in data integration across different omics platforms.
- Perform histopathological assessments of lung tissues to evaluate injury severity and resolution processes.
- Maintain accurate and detailed experimental records, analyze data, and contribute to the interpretation of results.
- Collaborate with the Principal Investigator and other team members to design experiments, optimize protocols, and develop new methodologies as needed.
- Prepare and present research findings in team meetings, and contribute to the writing of manuscripts for publication.
- Ensure compliance with animal care protocols and institutional safety regulations.
Required Education
Bachelor?s Degree required in degree in Molecular Biology, Biochemistry, Physiology, or a related field.
Required Experience
- Strong experience with animal handling and in vivo models, particularly with murine models of lung injury.
- Proficiency in molecular biology techniques, including RNA extraction, PCR, and data analysis of transcriptomics and metabolomics.
- Experience with histology and immunohistochemistry (IHC) is highly desirable.
Additional Qualifications Considered
- At least 2 years of relevant research experience.
- Master's degree in Molecular Biology, Biochemistry, Physiology, or a related field.
- Knowledge of single-cell RNA sequencing or other high-throughput sequencing methods is ideal.
- Excellent analytical and problem-solving skills, with the ability to interpret complex data sets.
- Strong organizational skills, attention to detail, and ability to work both independently and as part of a team.
- Effective communication skills, both written and verbal, to contribute to manuscript preparation and presentations.
- Experience in multi-omic data analysis and bioinformatics.
- Familiarity with lung pathology, especially in the context of acute lung injury or ARDS.
- Knowledge of the inflammatory response and cellular mechanisms of lung injury.
Physical Requirements/Work Environment
- Sitting - Continuously
- Repetitive hand motion (such as typing) - Often
- Hearing, listening - Often
- Talking - Often
- Standing - Often
- Walking - Often
- Bending - Often
- Stooping - Often
- Kneeling, squatting - Seldom
- Lifting - up to 20 pounds - Often
- Noise: There is sufficient noise to cause you to shout in order to be heard above the noise level.
- Hazards: Includes a variety of physical conditions, such as proximity to moving mechanical parts of machinery or tools used to perform work, moving vehicles, electrical current, working on scaffolding and high places, or exposure to chemicals.
- Atmospheric Conditions: Conditions that affect the respiratory system, such as fumes, odors, dusts, mists, gases, or poor ventilation.
Compensation and Benefits
UC offers a wide array of complementary and affordable benefit options, to meet the financial, educational, health, and wellness needs of you and your family. Eligibility varies by position and FTE.
- Competitive salary range of $45,000 - $70,000 dependent on the candidate's experience.
- Comprehensive insurance plans including medical, dental, vision, and prescription coverage.
- Flexible spending accounts and an award-winning employee wellness program, plus an employee assistance program.
- Financial security via our life and long-term disability insurance, accident and illness insurance, and retirement savings plans.
- Generous paid time off work options including vacation, sick leave, annual holidays, and winter season days in addition to paid parental leave.
- Tuition remission is available for employees and their eligible dependents.
- Enjoy discounts for on and off-campus activities and services.
For questions about the UC recruiting process or to request accommodations with the application, please contact Human Resources at jobs@uc.edu.
The University of Cincinnati is an Equal Opportunity Employer.
REQ: 97777