The Jiang Laboratory in the Departments of Genetics at Yale School of Medicine seeks a highly motivated candidate for an Associate Research Scientist position.

About the Lab

The Jiang Laboratory studies neurodevelopmental and neurogenetic disorders caused by genetic or epigenetic defects. The Lab is interested in the clinical presentations of these disorders and the potential new biology implicated. Our ultimate goals are to discover new biology and develop novel therapies for these disorders in humans.

We employ genomics approaches to discover the molecular basis of neurodevelopmental and neurogenetic disorders such as autism spectrum disorder, intellectual disability, Phelan-McDermid, Angelman, and Prader-Willi syndrome. We ask important questions how the deficiency of genes such as SHANK2, SHANK3, UBE3A, TET3, HIST1H1E, and SNORD116 lead to the impairment of neurodevelopment and what are the mechanism at molecular and circuit levels.

We study these questions using in vitro models of patient IPSC derived neurons and brain organoid and in vivo of mutant mice and employ multidisciplinary experimental approach of combing molecular, epigenetic, cellular, synaptic physiology, optogenetics, and behavioral techniques.

Primary Responsibilities:

The ideal candidate must be able to do the following:

• Participate and assist the principal investigator with conducting NIH supported studies and projects on genomic discoveries of rare and undiagnosed disease and developing CRISPR based editing treatments for neurogenetic and neurodevelopmental disorders. 
• Conduct experiments related to molecular genetics and epigenetic analysis, CRISPR editing, patient derived IPSC and brain organoids, and phenotypic analyses of mutant mice. 
• Must be able to work effectively and enthusiastically in a large team environment. 
• Must be prepared to work on genomic studies of rare disease, preclinical and FDA IND studies to develop new treatment, data collection and analysis, research and grant reporting, IRB protocol development, and must be able to communicate with investigators at Yale, other institutes, and program officers at the NIH. 
• Must have a demonstrated proven track record of scientific productivity.
• Must have excellent scientific writing and oral communication skills as projects will be highly collaborative. 

About the Department

The Department of Genetics believes that diversity drives outstanding science. We strive to create an inclusive community of faculty, staff, and students that promotes and values diversity in age, gender identity, race, sexual orientation, physical or mental ability, and ethnicity to represent better the communities we serve. Please refer to the official Yale School of Medicine statement on diversity and inclusion, accessible here: https://medicine.yale.edu/diversity/

Equal Employment Opportunity Statement

Yale University is an Affirmative Action/Equal Opportunity employer. Yale values diversity among its students, staff, and faculty and strongly welcomes applications from women, persons with disabilities, protected veterans, and underrepresented minorities.

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Applications should include a cover letter, curriculum vitae, a statement of research interests and career goals (up to 2 pages). Complete applications and letters of recommendation should be uploaded through Yale?s Interfolio website: http://apply.interfolio.com/157243

Review of applications will begin immediately and continue until the position is filled. All questions should be addressed to yong-hui.jiang@yale.edu.

About Yale University

Yale University is an American private Ivy League research university located in New Haven, Connecticut. Founded in 1701 in the Colony of Connecticut, the university is the third-oldest institution of higher education in the United States.

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