Postdoctoral Research Associate (Genetics and Genomics of Neurodegeneration) - Psychiatry
Washington University in St. Louis
Application
Details
Posted: 06-Oct-24
Location: ST. LOUIS, Missouri
Type: Full-time
Internal Number: JR84967
Position Summary
The Cruchaga Lab at Washington University School of Medicine is recruiting multiple Postdoctoral Research Associates. The NeuroGenomics and Informatics Center generates and analyzes Whole-Genome Sequencing data and high-throughput, multi-dimensional -omic data to study neurodegeneration and diseases of the central nervous system, with an emphasis on Alzheimer disease, Parkinsonâ™s disease, and other dementias. The ultimate goal of the NGI is to understand the biology of these diseases, to define novel biomarkers, and to identify novel therapeutic targets. The Washington University School of Medicine is renowned for its research cohorts of neurodegenerative disorders, which include clinical, neuroimaging, and fluid biomarker phenotypes.
Characterization of the genetic topography of Alzheimer's disease (AD) provides a unique opportunity to understand the disease. We are looking for investigators with expertise in Whole Genome and Exome data, colocalization, Mendelian Randomization, and TWAS/Fusion approaches to lead our effort to identify new genes involved in AD etiology.
Fernandez et al., âœGenetic and multi-omic resources for Alzheimer disease and related dementia from the Knight Alzheimer Disease Research Centerâ, Sci Data. 2024 PMID: 38997326
Cruchaga et al., âœNovel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracell signaling pathwaysâ, Res Sq, 2024. PMID: 38883718
Wang et al., âœProteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer's diseaseâ, Mol Neurodegenr. 2024. PMID: 38172904
Ray et al. âœThe Early-Onset Alzheimer's Disease Whole-Genome Sequencing Project: Study design and methodologyâ, Alzheimers Dement. 2023, PMID: 37390458
Ali et al., âœLarge multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer diseaseâ, Acta Neuropathol Commun, 2023 PMID: 37101235
Working Conditions
This position works in a laboratory environment with potential exposure to biological and chemical hazards. The individual must be physically able to wear protective equipment and to provide standard care to research animals.
Salary Range
Base pay is commensurate with experience.
The above statements are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all job duties performed by the personnel so classified. Management reserves the right to revise or amend duties at any time.
Required Qualifications
Education:
Ph.D., M.D. Or Equivalent Terminal Or Doctoral Degree.
Certifications:
No specific certification is required for this position.
Work Experience:
No specific work experience is required for this position.
Skills:
Not Applicable
Driver's License:
A driver's license is not required for this position.
More About This Job
Required Qualifications
A PhD in Genetics, Bioinformatics, Computer Science, Data Science, Statistical Genomics, or a related discipline involving the interrogation of â˜omicsâ™ datasets, or expect to obtain a degree in the near future.
Hands-on experience using PLINK, SKAT, FUSION, BWA, and/or GATK with large-scale human genomic or other omics (preferably related to neurodegeneration) studies.
For frequently asked questions about the application process, please refer to our External Applicant FAQ.
Accommodation
If you are unable to use our online application system and would like an accommodation, please email CandidateQuestions@wustl.edu or call the dedicated accommodation inquiry number at 314-935-1149 and leave a voicemail with the nature of your request.
All qualified individuals must be able to perform the essential functions of the position satisfactorily and, if requested, reasonable accommodations will be made to enable employees with disabilities to perform the essential functions of their job, absent undue hardship.
Pre-Employment Screening
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.
Benefits Statement
Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status, full-time equivalent (FTE) workload, and weekly standard hours. Please visit our website at https://hr.wustl.edu/benefits/ to view a summary of benefits.
EEO/AA Statement
Washington University in St. Louis is committed to the principles and practices of equal employment opportunity and especially encourages applications by those from underrepresented groups. It is the Universityâ™s policy to provide equal opportunity and access to persons in all job titles without regard to race, ethnicity, color, national origin, age, religion, sex, sexual orientation, gender identity or expression, disability, protected veteran status, or genetic information.
Diversity Statement
Washington University is dedicated to building a diverse community of individuals who are committed to contributing to an inclusive environment â“ fostering respect for all and welcoming individuals from diverse backgrounds, experiences and perspectives. Individuals with a commitment to these values are encouraged to apply.
Washington University in St. Louis, a medium-sized, independent university, is dedicated to challenging its faculty and students alike to seek new knowledge and greater understanding of an ever-changing, multicultural world. The University offers more than 90 programs and almost 1,500 courses leading to bachelor's, master's and doctoral degrees in a broad spectrum of traditional and interdisciplinary fields, with additional opportunities for minor concentrations and individualized programs. The faculty is composed of scholars, scientists, artists and members of the learned professions. They serve society by teaching; by adding to the store of human art, creativity, understanding, and wisdom; and by providing direct services, such as health care.