A cover letter is required for consideration for this position and should be attached as the first page of your CV.  The cover letter should state your scientific background, interests, and career goals. Applicants should also include at least three references, including name, phone number, email address, and in what capacity and how long you have known the reference.

The Kalantry Laboratory in the Department of Human Genetics at the University of Michigan Medical School is seeking a postdoctoral research fellow to join our interdisciplinary and highly interactive laboratory team focused on elucidating principles of epigenetic inheritance through the study of mammalian X chromosome dosage compensation.  X chromosome dosage compensation is a step-wise process that culminates in the transcriptional inactivation of one of the two X chromosomes in females and equalizes X-linked gene expression between the sexes.  X-inactivation is an evolutionarily conserved paradigm of epigenetic regulation and lies at the nexus of functional long noncoding (lnc) RNAs and chromatin-modifying factors.  

The Kalantry Lab has discovered new lncRNAs and identified chromatin modifying proteins with previously unknown functions in X-inactivation.  Recent findings from the lab further point to ancestral X chromosome dosage compensation mechanisms that predate the advent of X-inactivation and is funded by a 2024 NIH Director's Transformative Research Award.  These and other projects involve genetic and biochemical dissection of dosage compensation in cultured stem cells and in mice.  The postdoctoral fellow will have opportunities to take projects with them to their independent position.  

Lab website: https://kalantry.lab.medicine.umich.edu
Department website: https://medicine.umich.edu/dept/human-genetics/sundeep-kalantry-phd

• Work closely with others in the laboratory to genetically and epigenetically dissect X-chromosome inactivation in a variety of model systems, including mouse, rat, and human stem cells and mouse and rat embryos. 
• Take initiative and develops new concepts and techniques.
• Read the relevant scientific literature deeply.  
• Attend and presents seminars and participates in joint lab meetings.
• Prepare manuscripts for publication and presents findings at national meetings. 
   

• Ph.D. in developmental biology, genetics, and/or epigenetics or related fields.
• Expertise in molecular biology, cell culture, and/or biochemistry. 
• Highly motivated, organized individual with a demonstrated track record of innovation and independent direction. 
• Ability to work collaboratively, take initiative, and complete projects.  
• A strong publication record with one or more first-author publication(s).

• Ability to analyze high-throughput datasets.  
• Experience with advanced statistical methods.

Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings.  Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.

The University of Michigan is an equal opportunity/affirmative action employer.

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