General Description

The O'Brien Lab in the Department of Biophysics and Biophysical Chemistry at the Johns Hopkins University School of Medicine recently opened in August of 2024, and seeks a postdoctoral fellow interested in the discovery and mechanistic characterization of new G-protein coupled receptor (GPCR) ligands as drug leads with a variety of cutting-edge technologies. This work will involve membrane protein biochemistry, selection methodologies, structural biology (cryo-EM), and protein dynamics techniques. This work will be extremely multidisciplinary and involve collaboration across many areas of the drug discovery pipeline, with expertise gained in nearly all areas of early drug discovery. The target start date is negotiable.

Dr. Evan O'Brien did his graduate work at the University of Pennsylvania where he used solution nuclear magnetic resonance (NMR) techniques to demonstrate the highly dynamic nature of methyl-bearing side chains in membrane proteins. He followed this up with postdoctoral work in the lab of Dr. Brian Kobilka at Stanford University where he worked towards both characterizing complex mechanisms of allosteric modulation of human GPCRs and discovering and demonstrating the utility of novel small molecule GPCR allosteric modulators. This work resulted in the discovery of the first class of opioid receptor negative allosteric modulators as well as demonstrated their distinct mechanism of activity.

Qualifications

Candidates will have a strong background in protein biochemistry/biophysics, cryo-EM, protein dynamics, and/or computational biology, have a sense of independence, and should be motivated to learn and perfect a wide array of skills/techniques. The postdoc will have a central role in starting the lab, developing GPCR drug discovery efforts at Johns Hopkins, and fostering an open and collaborative environment for membrane protein biophysics throughout the rich scientific community at Johns Hopkins. Applicants must also have excellent communication skills. The applicant must have a Ph.D. (or equivalent) in a related field by the start date.

Application Instructions

Interested applicants should apply directly to Dr. O'Brien by sending cover letter (especially indicating future project and technique interests), C.V., and contact information for three references to: eobrie26@jh.edu.

 

Department: http://biophysics.med.jhmi.edu/

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About Johns Hopkins University

Johns Hopkins University remains committed to its founding principle, that education for all students should be grounded in exploration and discovery. Hopkins students are challenged not just to learn but also to advance learning itself. Critical thinking, problem solving, creativity, and entrepreneurship are all encouraged and nourished in this unique educational environment. After more than 130 years, Johns Hopkins remains a world leader in both teaching and research. Faculty members and their research colleagues at the university's Applied Physics Laboratory have each year since 1979 won Johns Hopkins more federal research and development funding than any other university. The university has nine academic divisions and campuses throughout the Baltimore-Washington area. The Krieger School of Arts and Sciences, the Whiting School of Engineering, the School of Education and the Carey Business School are based at the Homewood campus in northern Baltimore. The schools of Medicine, Public Health, and Nursing share a campus in east Baltimore with The Johns Hopkins Hospital. The Peabody Institute, a leading professional school of music, is located on Mount Vernon Place in downtown Bal...timore. The Paul H. Nitze School of Advanced International Studies is located in Washington's Dupont Circle area.

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