Position Description The research group of Professor Gingeras at Cold Spring Harbor Laboratory investigates the storage of functional information within genomes, crucial for understanding how gene mutations impact biological and clinical outcomes in humans and other organisms. His leadership in large-scale projects like ENCODE has revealed that genomes, from bacteria to humans, undergo pervasive transcription generating noncoding RNAs (ncRNAs), which play diverse roles beyond protein production, including in gene regulation and cellular signaling. This research is pivotal for mapping RNA transcription across genomes, influencing various aspects of disease diagnosis and treatment, such as the dysregulation of PTEN by ncRNAs like HOTAIR in endometrial cancer, particularly in obes