Scheduled Hours

40

Position Summary

Alzheimerâ™s disease (AD) is a highly heterogeneous multifactorial disease. Genetic influences on AD are strong as shown by several pathogenic genes and over 50 AD loci identified through genome-wide association studies (GWAS). There are also clear sex differences in AD risk and progression. Women are at a higher risk of developing AD and present faster progression. A recent GTEx study also highlights sex differences in the genetic regulation of gene expression. Despite these established sex differences, sex-specific molecular findings in AD are still limited. The objective of our team is to generate detailed sex-specific multi-tissue molecular profiles of AD and decipher the genetic architecture that underlies AD. To identify sex-specific functional mechanisms underlying the genetic architecture of AD, we have generated multiple layers of -omics data, including DNA methylation, gene expression, proteomics, metabolomics, and lipidomics, from several large and well characterized studies. A series of well-powered sex-specific omics characterization across multiple tissues can help identify novel drug targets and provide critical insights for clinically translatable interventions for prevention and treatment. We aim to map additional GWAS loci by performing sex-specific multi-omic quantitative trait loci and co-localization for each -omic layers. We aim to identify the causal genes, proteins, and additional -omic analytes by performing Mendelian randomization. Analyzing such omics data will elucidate a causal path from sex-specific genetic variation to AD risk, onset and progression.

This position collaborates on designing, conducting and reporting of research projects.

Job Description

Primary Duties and Responsibilities

• Collaborates with the PI on the design, conduct and reporting of research projects.
• Assists with grant preparation and reporting. May submit grant proposals in rare circumstances with the approval of the PI, Department Head and Dean.
• Prepares and submits papers on research.
• Develops hypotheses to be tested and ways of testing it.
• Complies with established safety procedures and maintaining required documentation on laboratory and specimen conditions.
• Manages research project with other institutions and investigators.
• Performs other duties as assigned.

Working Conditions

This position works in a laboratory environment with potential exposure to biological and chemical hazards. The individual must be physically able to wear protective equipment and to provide standard care to research animals.

Preferred Qualifications

• Four years of postdoctoral experience.
• Experience in a laboratory setting working with iPSC cell culture.
• Knowledge of the brain system and its cell types.
• Experience in differentiation of iPSC into neural cell lines.
• Experience with DNA extraction, PCR/qPCR, ELISA, ICC/IHC/IF, and gene editing techniques (transduction, transfection, CRISPR).
• Strong publication record.
• Mouse colony management and rodent handling.
• Scientific and grant writing experience.
• Analytical reasoning and problem-solving skills.
• Demonstrated working knowledge of standard laboratory policies, procedures and equipment.
• Ability to communicate in oral and written form with all levels of personnel and technical publications.
• Ability to work well independently or as a team member.

Required Qualifications

PhD, M.D. or equivalent terminal degree and at least 3 years of postdoctoral experience; or an equivalent combination of education and experience equaling 12 years.

Grade

R12

Salary Range

$63,400.00 - $115,000.00 / Annually

The salary range reflects base salaries paid for positions in a given job grade across the University. Individual rates within the range will be determined by factors including one's qualifications and performance, equity with others in the department, market rates for positions within the same grade and department budget.

Questions

For frequently asked questions about the application process, please refer to our External Applicant FAQ.

Accommodation

If you are unable to use our online application system and would like an accommodation, please email CandidateQuestions@wustl.edu or call the dedicated accommodation inquiry number at 314-935-1149 and leave a voicemail with the nature of your request.

Pre-Employment Screening

All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.

Benefits Statement

Personal

• Up to 22 days of vacation, 10 recognized holidays, and sick time.

• Competitive health insurance packages with priority appointments and lower copays/coinsurance.

• Want to Live Near Your Work and/or improve your commute? Take advantage of our free Metro transit U-Pass for eligible employees. We also offer a forgivable home loan of up to $12,500 for closing costs and a down payment for homes in eligible neighborhoods.

• WashU provides eligible employees with a defined contribution (403(b)) Retirement Savings Plan, which combines employee contributions and university contributions starting at 7%.

Wellness

• Wellness challenges, annual health screenings, mental health resources, mindfulness programs and courses, employee assistance program (EAP), financial resources, access to dietitians, and more!

Family

• We offer 4 weeks of caregiver leave to bond with your new child. Family care resources are also available for your continued childcare needs. Need adult care? Weâ™ve got you covered.

• WashU covers the cost of tuition for you and your family, including dependent undergraduate-level college tuition up to 100% at WashU and 40% elsewhere after seven years with us.

For policies, detailed benefits, and eligibility, please visit: https://hr.wustl.edu/benefits/

EEO/AA Statement

Washington University in St. Louis is committed to the principles and practices of equal employment opportunity and especially encourages applications by those from underrepresented groups. It is the Universityâ™s policy to provide equal opportunity and access to persons in all job titles without regard to race, ethnicity, color, national origin, age, religion, sex, sexual orientation, gender identity or expression, disability, protected veteran status, or genetic information.

Diversity Statement

Washington University is dedicated to building a diverse community of individuals who are committed to contributing to an inclusive environment â“ fostering respect for all and welcoming individuals from diverse backgrounds, experiences and perspectives. Individuals with a commitment to these values are encouraged to apply.

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