Description: Each of us harbor biological timers in our bodies known as the circadian clock. These clocks drive physiological processes and behaviors in coordination with the day-night cycle. Recent work has provided evidence that the circadian clock regulates immune functions in coordination with the day-night cycle. However, the underlying mechanisms by which the circadian clock drives rhythms in immunity are ill-defined. The Brooks lab seeks to mechanistically determine circadian clock regulation of innate immune functions at the intestinal epithelial barrier. Forming the first line of defense, the intestinal epithelium must acquire nutrients from the diet while maintaining harmony with a vast consortium of microorganisms known collectively as the microbiota. Endemic to the epithelium are specialized epithelial and immune cell types that produce antimicrobial proteins, bolster the epithelial barrier, and coordinate immune responses. These fundamental functions of innate immunity are regulated by the time of day. The Brooks lab is seeking a postdoctoral candidate or more senior researcher to characterize the impact of clocks across the intestinal epithelial barrier on host defense. The successful candidate will join a highly collaborative group with strengths in cell biology, mouse genetics, and molecular biology. The P.I. is dedicated to providing a nurturing training environment with the acknowledgment that mentorship must be tailored to the individual. The ideal applicant will be highly motivated; have a Ph.D. degree; research experience in one or more of the following cell biology, molecular biology, biochemistry, bioinformatics, genetics, immunology, and/or microbiology; Fluent in English language and writing skills. Experience with one or more of the following is a plus: Flow cytometry, electron microscopy, bioinformatics, microscopy, or bacterial genetics. This appointment is for one year with the possibility of renewal pending satisfactory performance and availability of funding. Applications from members of groups historically under-represented in molecular biology are strongly encouraged. To apply, please submit a cover letter, CV, and three letters of recommendation to: https://puwebp.princeton.edu/AcadHire/position/25401 Review of the applications will begin on May 1st and will continue until the position is filled. This position is subject to the University's background check policy. Informal inquiries are also welcome: email firstname.lastname@example.org. Princeton University is an Equal Opportunity/Affirmative Action Employer and all qualified applicants will receive consideration for employment without regard to age, race, color, religion, sex, sexual orientation, gender identity or expression, national origin, disability status, protected veteran status, or any other characteristic protected by law. EEO IS THE LAW. No recruiters and no telephone calls please.
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