Senior Translational Research Investigator (Pathobiology)
University of Pennsylvania
Location: Philadelphia, Pennsylvania
Internal Number: 5008940
Senior Translational Research Investigator (Pathobiology)
The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn's distinctive interdisciplinary approach to scholarship and learning. As an employer Penn has been ranked nationally on many occasions with the most recent award from Forbes who named Penn one of America's Best Large Employers in 2023.
Penn offers a unique working environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide variety of atmospheres, Philadelphia is the perfect place to call home for work and play.
The University offers a competitive benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and resources, and much more.
Posted Job Title Senior Translational Research Investigator (Pathobiology)
Job Profile Title Research Investigator, Senior
Job Description Summary We are seeking an ambitious and highly motivated clinician scientist to lead studies focused on adoptive cellular therapies and antibody targeted therapies to treat spontaneous diseases in companion dogs.
The position will include advanced training in comparative immunology and immunobiology. Applicants must have a DVM or equivalent veterinary degree and a minimum of 5 years of experience. Completion of an internship and/or residency program in internal medicine, critical care, or oncology is required. Candidates with a keen interest in clinical medicine and advanced training in immunology/immunobiology (Masters, PhD) are preferred. The selected candidate will learn all aspects of running a clinical-translational research program and prepare the selected candidate for a successful future academic or industry related career.
In the translational research lab, the successful candidate will employ the latest tools supported by Penn's core facilities, including high dimensional flow cytometry, multiplex IHC/IF, and bulk and scRNAseq to identify correlative biomarkers of response. The selected candidate will work as an integral part of a comparative translational research team and assume primary case responsibility for canine patients enrolled in ongoing federal and privately funded immunotherapy clinical trials. They will gain practical experience in the use of immunotherapies alone, or in combination with other treatment modalities, utilizing the full range of capabilities in a large, well equipped, modern veterinary teaching hospital. In addition, the successful candidate will receive advanced training in cell-based immunotherapy technology, next-generation immune cell engineering, in vitro functional assays and analysis, next generation imaging platforms including spatial profiling and bioinformatics.
Development and implementation of clinical trial protocols, primary case responsibility and clinical management of companion dogs receiving immunotherapies, client communications, referring veterinarian communications etc
Assessment of cellular products and clinical responses to immune therapies
Functional in vitro assays (proliferation, cytokine production, cytotoxicity etc), next generation sequencing, bioinformatics etc
Development of next generation cellular therapies including cell culture, vector generation, transduction, electroporation etc
Manuscript and protocol development and write ups, presentations, abstract +/- grant writing
Further career development opportunities, including seminars, conferences and graduate courses
Perform additional duties as assigned
Position contingent upon funding.
Education and Qualifications:
DVM or equivalent veterinary degree and a minimum of 5 years of experience. Completion of an internship and/or residency program in internal medicine, critical care, or oncology is required. Candidates with a keen interest in clinical medicine and advanced training in immunology/immunobiology (Masters, PhD) are preferred.
Physical & Working Conditions:
Office, library, computer room; Exposure to chemicals; On-Call (beeper); [ Requires protective devices;Typically sitting at a desk or table; Occasional lifting 25-50 lbs; Typically standing or walking; Typically bending, crouching, stooping and Intermittently sitting/standing/stooping
Job Location - City, State Philadelphia, Pennsylvania
Department / School School of Veterinary Medicine
Pay Range $36,368.00 - $120,000.00 Annual Rate Salary offers are made based on the candidate's qualifications, experience, skills, and education as they directly relate to the requirements of the position, as well as internal and market factors and grade profile.
Affirmative Action Statement Penn adheres to a policy that prohibits discrimination on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected class.
Special Requirements Background check required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.
Health, Life, and Flexible Spending Accounts: Penn offers comprehensive medical, prescription, behavioral health, dental, vision, and life insurance benefits to protect you and your family's health and welfare. You can also use flexible spending accounts to pay for eligible health care and dependent care expenses with pre-tax dollars.
Tuition: Take advantage of Penn's exceptional tuition benefits. You, your spouse, and your dependent children can get tuition assistance here at Penn. Your dependent children are also eligible for tuition assistance at other institutions.
Retirement: Penn offers generous retirement plans to help you save for your future. Penn's Basic, Matching, and Supplemental retirement plans allow you to save for retirement on a pre-tax or Roth basis. Choose from a wide variety of investment options through TIAA and Vanguard.
Time Away from Work: Penn provides you with a substantial amount of time away from work during the course of the year. This allows you to relax, take vacations, attend to personal affairs, recover from illness or injury, spend time with family-whatever your personal needs may be.
Long-Term Care Insurance: In partnership with Genworth Financial, Penn offers faculty and staff (and your eligible family members) long-term care insurance to help you cover some of the costs of long-term care services received at home, in the community or in a nursing facility. If you apply when you're newly hired, you won't have to provide proof of good health or be subject to underwriting requirements. Eligible family members must always provide proof of good health and are subject to underwriting.
Wellness and Work-life Resources: Penn is committed to supporting our faculty and staff as they balance the competing demands of work and personal life. That's why we offer a wide variety of programs and resources to help you care for your health, your family, and your work-life balance.
Professional and Personal Development: Penn provides an array of resources to help you advance yourself personally and professionally.
University Resources: As a member of the Penn community, you have access to a wide range of University resources as well as cultural and recreational activities. Take advantage of the University's libraries and athletic facilities, or visit our arboretum and art galleries. There's always something going on at Penn, whether it's a new exhibit at the Penn Museum, the latest music or theater presentation at the Annenberg Center, or the Penn Relays at Franklin Field to name just a few examples. As a member of the Penn community, you're right in the middle of the excitement-and you and your family can enjoy many of these activities for free.
Discounts and Special Services: From arts and entertainment to transportation and mortgages, you'll find great deals for University faculty and staff. Not only do Penn arts and cultural centers and museums offer free and discounted admission and memberships to faculty and staff. You can also enjoy substantial savings on other goods and services such as new cars from Ford and General Motors, cellular phone service plans, movie tickets, and admission to theme parks.
Flexible Work Hours: Flexible work options offer creative approaches for completing work while promoting balance between work and personal commitments. These approaches involve use of non-traditional work hours, locations, and/or job structures.
Penn Home Ownership Services: Penn offers a forgivable loan for eligible employees interested in buying a home or currently residing in West Philadelphia, which can be used for closing costs or home improvements.
Adoption Assistance: Penn will reimburse eligible employees on qualified expenses in connection with the legal adoption of an eligible child, such as travel or court fees, for up to two adoptions in your household.
Penn has a long and proud tradition of intellectual rigor and pursuit of innovative knowledge, begun by Benjamin Franklin in 1740. That tradition lives today through the creativity, entrepreneurship, and engagement of our faculty, students, and staff. Academic life at Penn is unparalleled, with an undergraduate student body of 10,000 from every U.S. state and around the world. The entering class of 2015 is the most talented and diverse in Penn's history. Consistently ranked among the top 10 universities in the country, Penn welcomes an additional 10,000 students to our top-ranked graduate and professional schools.