A research technician position is open to join the laboratory of Dr. Kathleen Burns in the Department of Oncologic Pathology at Dana-Farber Cancer Institute. Our group studies high copy number repeats in the human genome, and the biology of the retrotransposons and endogenous retroviruses that generate these sequences. We and others have shown that subsets of these normally silenced elements are expressed as a hallmark of human cancers, and that this results in somatically-acquired retrotransposon insertions in cancer genomes. We aim to more fully characterize this phenomenon; to probe its consequences for cancer biology using models of cancer growth and tumor immunology; and to leverage our understandings to inform cancer detection and treatment. Specifically, we are devoting sign
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