The University of Alabama at Birmingham (UAB), Genetics Research Division, is seeking a highly motivated Researcher II to join the Xu Laboratory.
The Xu Lab employs a multi-disciplinary approach including Single-Cell sequencing, Proteolysis targeting chimeric (PROTAC) technology, multiomics, biochemistry, organoid and in vivo mouse model to interrogate the regulation of the mitosis program by oncogenic signaling pathways in cancer cells and explore new therapeutic strategies for targeting cancer aneuploidy and chromosome instability (CIN). Additionally, Dr. Xu has a long-term interest in translating basic research findings into clinical application to develop novel targeted therapies, gene therapies based on Adeno-associated virus (AAV) vector-mediated gene delivery or Lipid nanoparticles (LNP)-mediated mRNA delivery, and immunotherapies. We are particularly interested in PI3K/AKT/PTEN pathway and KRAS pathway. Our disease focus is solid tumors with emphasis on breast cancer and prostate cancer. More specifically, the research involves small molecule screening using western blot analysis and in vitro testing of candidate molecules using colony formation assay and Incucyte experiment. It requires knowledge of basic Cell and molecular biology lab techniques, western blot, DNA/RNA extraction as well as (q)PCR/RT-(q)PCR, DNA cloning (ligation, transformation), gel electrophoresis (agarose, polyacrylamide), cell culturing experiments, transfection/transduction, and cell imaging.
To set up and perform routine and established lab procedures in support of lab goals.
To collect, enter and summarize data.
To monitor results and report unusual outcomes.
Key Duties & Responsibilities
Sets up and performs routine and established lab procedures in support of lab goals. Runs assays, cell/tissue culture, animal studies, etc.
Collects, enters and summarizes data.
Monitors results; detects and reports unusual outcomes.
Assists in the maintenance and trouble-shooting of lab equipment and supplies.
Performs basic statistical data analysis.
Performs fundamental statistical data analysis.
Performs other duties as assigned.
Hourly Salary Range$15.50 - $23.51
Bachelor's degree in a related field
OR Associate's degree in a related field and two (2) years of related experience
OR High School diploma or GED and four (4) years of related experience
Work experience may NOT substitute for education requirement.
Master's degree in a biology or a related field and two (2) years of related experience OR Bachelor's degree in a related field and four (4) years of related experience.
Prior experience with cell and molecular biology lab techniques, western blot, DNA/RNA extraction as well as (q)PCR/RT-(q)PCR, DNA cloning (ligation, transformation), gel electrophoresis (agarose, polyacrylamide), cell culturing experiments, transfection/transduction, and cell imaging.
:392704000 Genetics Research Div
Work Arrangement (final schedule to be determined by the department/hiring manager):Onsite
In fall 2018, UAB had a third consecutive year of record-high over all enrollment with 21,923 students, including its largest freshman class ever (2,299), with enrollment growth in every school on campus and in the acclaimed UAB Honors College. The freshman class had an average ACT of 25.2 and GPA of 3.73- both higher than 2017. UAB's students are talented and diverse, with minority students making up 40.5 percent of the freshman class and 39.7 percent of the entire of the student body. Logo Logo UAB is was recently recognized as the Top Young University in the U.S. and 10th globally in the Times Higher Education World University Rankings. UAB research expenditures are at a record high, exceeding $562 million in FY17, and UAB ranks 15th in federal funding nationally among public universities (top 4 percent) and 31st overall (top 5 percent). In National Institutes of Health funding, UAB ranks 8th among public universities (top 2 percent) and 23rd overall (top 4 percent) with more than $244 million. UAB Health system has over one million patient visits annually and is home to Alabama's largest hospital and the 3rd largest public hospital in the U.S. UAB houses the state's only level ...1 adult trauma center and the only National Cancer Institute-designated Comprehensive Cancer Center in Alabama and a five-state region. UAB is the state's largest single-site employer, with more than 23,000 employees, and has an annual economic impact of over $7.15 billion on Alabama.