SCHOOL/UNIT DESCRIPTION: Sarafan ChEM-H is a new interdisciplinary institute focused on connecting Chemistry, Engineering, and Medicine for Human Health. The institute was founded as a joint venture of the Schools of Medicine, Engineering, and Humanities and Sciences. The proximity of world-class biologists, chemists, engineers, and clinicians at Stanford presents a unique opportunity to study human biology at a molecular level, to translate this knowledge into groundbreaking products and services that promote healthy living, and to educate a new cadre of "physician-scientist-engineers" who will lead a rapidly evolving industry. The institute's Knowledge Centers serve as shared laboratories where trainees from diverse disciplines in science, engineering and medicine pursue projects under the mentorship of the center's Directors, thereby gaining hands-on skills in high-throughput screening, medicinal chemistry, metabolomics, protein chemistry, and structural biology.
The Innovative Medicines Accelerator (IMA) emerged out of Stanford's Long Range Vision and seeks to accelerate the translation of Stanford research discoveries into new medicines while expanding our knowledge of human biology. Part of the Drug and Vaccine Prototyping arm of the IMA, the Cell and Gene Therapies portfolio focuses on supporting novel therapeutic development in these research areas through annual seed grant opportunities and internal and external partnerships.
Our VPDoR Diversity Journey:
We create a hub of innovation through the power of diversity of disciplines and people.
We provide equitable access and opportunity to all members of the community in order to do their best work, regardless of race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.
We listen to and value all colleagues who bring diverse perspectives to the advancement and development of a respectful community.
We promote a culture of belonging, equity, and safety.
We embed these values in excellence of education, research, and operation.
POSITION SUMMARY: The Innovative Medicines Accelerator (IMA) / Sarafan ChEM-H is seeking a highly motivated Research Scientist, Protein Biochemistry with deep expertise in AKTA based protein purification, preferably Adeno Associated Viral (AAV) vectors. Our goal is to take advantage of the tremendous promise of AAV vectors in treating rare genetic disorders. As such, they will be responsible for manufacturing novel AAV vectors for a diverse portfolio at the IMA. Primary duties will be to take full responsibility for all AAV production and quality control assays. Additional duties include operation and maintenance of equipment associated with AAV production, and with opportunities to implement new technologies for process optimization. Candidates should have strong organizational skills and be coordinated and methodical in their scientific approach. Ideally, they are excellent team players, self-motivated, comfortable with autonomy, and embrace opportunities to tackle new problems and challenges as part of a dynamic team in a start-up-like environment within the University. Emphasis is placed on communicative teamwork, while also being able to take initiative and work independently. Expertise in molecular biology techniques like dd-PCR, DNA/protein gels etc. is highly preferred.
CORE DUTIES:
Support scientific and research programs related to the area of cell and gene therapy; analyze data, monitor and oversee experimental processes, and design and develop prototypes, specialized equipment, and/or systems.
Plan and execute various phases of AAV vector production operation, oversee schedule of key operational equipment, and supervise their routine maintenance.
Acquire and maintain tools, equipment, and chemicals associated with vector production and quality control.
Maintain documentation related to research studies and protocols, and perform administrative duties related to equipment and systems associated with research or engineering projects, as assigned.
Liaise between cell & gene therapy and IMA members and serve as a resource for AAV production and quality control.
Routinely carry out molecular biology techniques like dd-PCR, DNA/protein gels.
Routine aseptic handling of AAV production cells and other cell lines as required.
MINIMUM REQUIREMENTS: Education & Experience: Associate degree or certificate of completion in a related engineering or related scientific discipline, or three years of equivalent work experience or combination of education and relevant experience.
Knowledge, Skills and Abilities:
Experience applying scientific and engineering principles and practices to perform technical services and support.
Experience with data analysis, experimental process, design, and development of prototypes, equipment, and/or systems related to AAV vector production and purification.
Ability to write clear documentation, perform administrative duties, and research protocol maintenance related to research studies and/or scientific projects.
Experience with software applications, systems, or programs relevant for the job.
Ability to interpret and determine validity of data and check own work.
Ability to communicate, liaise, and work with IMA staff.
PREFERRED QUALIFICATIONS:
A bachelor's degree with 4+ years or a Master's degree with 2+ years or a PhD with 0-2 years experience in academia and/or industry experience in protein purification.
Experience in AAV gene therapy discovery research is highly preferred.
Extensive knowledge in AKTA protein purification system.
Ability to handle aseptic cell culture and basic molecular biology tools like PCR and gels.
Ability to prioritize own work and multi-task.
Demonstrated ability to take initiative and ownership of research processes.
Ability to routinely and independently exercise sound judgment in making decisions.
Experience working independently and as part of a team.
Ability to work with project management tools.
PHYSICAL REQUIREMENTS*:
Frequently grasp lightly/fine manipulation, perform desk-based computer tasks, lift/carry/push/pull objects that weigh up to 10 pounds.
Occasionally stand/walk, sit, twist/bend/stoop/squat, grasp forcefully.
Rarely kneel/crawl, climb (ladders, scaffolds, or other), reach/work above shoulders, use a telephone, writing by hand, sort/file paperwork or parts, operate foot and/or hand controls, lift/carry/push/pull objects that weigh >40 pounds.
* - Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of the job.
WORKING CONDITIONS:
May be exposed to high voltage electricity, radiation or electromagnetic fields, lasers, noise > 80dB TWA, Allergens/Biohazards/Chemicals /Asbestos, confined spaces, working at heights ?10 feet, temperature extremes, heavy metals, unusual work hours or routine overtime and/or inclement weather.
May require travel.
WORK STANDARDS:
Interpersonal Skills: Demonstrates the ability to work well with Stanford colleagues and clients and with external organizations.
Promote Culture of Safety: Demonstrates commitment to personal responsibility and value for safety; communicates safety concerns; uses and promotes safe behaviors based on training and lessons learned.
Subject to and expected to comply with all applicable University policies and procedures, including but not limited to the personnel policies and other policies found in the University's Administrative Guide, http://adminguide.stanford.edu.
The expected pay range for this position is $78,000 to $113,000 per annum. Stanford University provides pay ranges representing its good faith estimate of what the university reasonably expects to pay for a position. The pay offered to a selected candidate will be determined based on factors such as (but not limited to) the scope and responsibilities of the position, the qualifications of the selected candidate, departmental budget availability, internal equity, geographic location and external market pay for comparable jobs.
At Stanford University, base pay represents only one aspect of the comprehensive rewards package. The Cardinal at Work website (https://cardinalatwork.stanford.edu/benefits-rewards) provides detailed information on Stanford's extensive range of benefits and rewards offered to employees. Specifics about the rewards package for this position may be discussed during the hiring process.
Why Stanford is for You Imagine a world without search engines or social platforms. Consider lives saved through first-ever organ transplants and research to cure illnesses. Stanford University has revolutionized the way we live and enrich the world. Supporting this mission is our diverse and dedicated 17,000 staff. We seek talent driven to impact the future of our legacy. Our culture and unique perks empower you with:
* Freedom to grow. We offer career development programs, tuition reimbursement, or audit a course. Join a TedTalk, film screening, or listen to a renowned author or global leader speak. * A caring culture. We provide superb retirement plans, generous time-off, and family care resources. * A healthier you. Climb our rock wall, or choose from hundreds of health or fitness classes at our world-class exercise facilities. We also provide excellent health care benefits. * Discovery and fun. Stroll through historic sculptures, trails, and museums. * Enviable resources. Enjoy free commuter programs, ridesharing incentives, discounts and more!
The job duties listed are typical examples of work performed by positions in this job classification and are not designed to contain or be interpreted as a comprehensive inventory of all duties, tasks, and responsibilities. Specific duties and responsibilities may vary depending on department or program needs without changing the general nature and scope of the job or level of responsibility. Employees may also perform other duties as assigned.
Stanford is an equal employment opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.
Why work at Stanford?Stanford University has changed the world, over and over again.We are one of Silicon Valley's largest employers - and also one of the most unique. Our mission is to educate future leaders and promote interdisciplinary, world-class research and teaching. This passion makes Stanford an intensely creative, rewarding, and challenging place to work. At the same time, our traditions of respect and collaboration sustain a humane, supportive environment in which to pursue your life and your career.At Stanford you'll work with bright, diverse, dedicated people. You'll find encouragement to learn and grow. You'll enjoy excellent benefits and an outstanding environment. How will it change you?
