Position duration: 1 year with possibility of extension based on funding availability and employee performance.
Application Window Open date: November 14, 2023
Next review date: Tuesday, Nov 28, 2023 at 11:59pm (Pacific Time) Apply by this date to ensure full consideration by the committee.
Final date: Thursday, Dec 14, 2023 at 11:59pm (Pacific Time) Applications will continue to be accepted until this date, but those received after the review date will only be considered if the position has not yet been filled.
The Innovative Genomics Institute (IGI) is a multidisciplinary research institution focused on genome engineering and potential applications in agriculture, microbiology and biomedicine. It is a joint venture between UC Berkeley and UC San Francisco, with the administrative operations located on the Berkeley campus.
The IGI is presently seeking a highly motivated Assistant Project Scientist to perform research on molecular systems enabling the therapeutic delivery of genome editing reagents. This interdisciplinary work will be performed as part of a team at UC Berkeley, centered in the laboratory of Ross Wilson, IGI Director of Therapeutic Delivery.
Specific research activities will involve protein engineering to generate novel macromolecules supporting development of improved CRISPR-based genetic therapies. Major tasks will include molecular cloning, recombinant expression, protein purification, enzyme engineering, chemical biology, quality assessment, and preparation of novel genome editing enzymes for use in tissue culture experiments.
The Project Scientist will also collaborate with IGI investigators at UCB, UCSF, and other IGI-affiliated universities in the effort to advance the delivery of genome editing for therapeutic use. In addition to their own efforts, this Project Scientist will guide genome editing efforts of one or more research technicians and/or postdoctoral scholars. The Project Scientist will report directly to Ross Wilson.
Duties for this position include:
Obtain consistent and reliable data.
Manage multiple projects and tasks in parallel in order to meet program-based milestones.
Train one or more postdoctoral researchers and/or one or more technicians.
Collaborate with principal investigators, postdocs, and students at partner universities and provide input to their research teams.
Design and develop useful and practical intellectual property.
Contribute to high-quality, high-impact publications in peer-reviewed journals.
Attend scientific and technical conferences to discuss accomplishments at the IGI and establish relationships with other leaders in the field.
Qualifications Basic qualifications (required at time of application) PhD or equivalent international degree
Additional qualifications (required at time of start) Ph.D. or equivalent degree in Molecular Genetics, Cell Biology, Biochemistry, Bioengineering, or related discipline and a minimum 4 years of post-doctoral and/or industrial experience in a relevant field.
Proficient in genetic manipulation of mammalian cells using site-specific endonucleases.
Expertise in tissue culture, including iPSC-derived cultures and primary cells relevant to genetic therapeutic development.
Skilled in high-throughput screening for genome editing efficiency.
Mentorship ability in protein engineering and purification techniques.
Effective communication and collaboration with diverse researchers.
Innovative thinking with the ability to synergize ideas and approaches, while exercising sound judgment.
Willingness to travel occasionally as required.
Competent in the preparation of ribonucleoprotein complexes for genome editing experiments.
Knowledge of endotoxin removal methods and quality control.
Expertise in construct engineering, cloning techniques, mutagenesis, and other molecular biology techniques related to protein engineering.
Strong background in protein purification techniques, including affinity chromatography and size exclusion chromatography.
Experience in optimizing protein expression and purification protocols for high yields and purity.
Proven experience in designing and modifying recombinant Cas9 and deaminase domains for improved functionality and specificity.
Curriculum Vitae - Your most recently updated C.V.
Statement of Research
Statement on Contributions to Advancing Diversity, Equity, and Inclusion - Statement on your contributions to diversity, equity, and inclusion, including information about your understanding of these topics, your record of activities to date, and your specific plans and goals for advancing equity and inclusion if hired at Berkeley. More Information and guidelines. (Optional)
UC Berkeley is committed to diversity, equity, inclusion, and belonging. The excellence of the institution requires an environment in which the diverse community of faculty, students, and staff are welcome and included. Successful candidates will demonstrate knowledge and skill related to ensuring equity and inclusion in the activities of their academic position (e.g., teaching, research, and service, as applicable).
The University of California, Berkeley is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy see: http://policy.ucop.edu/doc/4000376/NondiscrimAffirmAct
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As a University employee, you will be required to comply with all applicable University policies and/or collective bargaining agreements, as may be amended from time to time. Federal, state, or local government directives may impose additional requirements.
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