The Department of Pediatrics is seeking a Researcher with a passion for applying their knowledge and skills to clinical challenges to join our multidisciplinary team of researchers and clinicians and support three related medical genomics-focused research projects based in the Center for Human Genomics and Precision Medicine (CHGPM) at the UW School of Medicine and Public Health. The UW Undiagnosed Diseases program takes a 'beyond the exome' approach to the diagnosis of rare genetic disorders that emphasizes long-read genome sequencing and RNA-Seq, as well as the role of structural variants and non-coding variants in disease. BadgerSeq is a Nanopore-based long-read genome sequencing project that will facilitate the ultra-rapid diagnosis of critically ill newborns. The third project focuses on characterizing genome instability in DNA repair deficiency/cancer predisposition syndromes.
The Researcher will be responsible for wet-bench genome sequencing workflows, from isolation of DNA and RNA from human material to preparation of sequencing libraries and the running of samples on in-house Illumina and Nanopore sequencers. The Research Specialist will work closely with our bioinformatician and the rest of our team to insure the production of consistent, high quality sequencing data. The Research Specialist also will process clinical samples and maintain human cell lines as well as participate in exploratory research utilizing additional molecular and cell biology techniques. In addition to carrying out basic data analysis and interpretation, the Research specialist will operate and maintain laboratory equipment, help train fellows and students, occasionally present in group and Center meetings, and contribute to research manuscripts. The successful applicant is expected to have outstanding organizational skills and record keeping, communicate well with faculty, trainees, and co-workers, and work well in a team-oriented environment.
Provides technical expertise to fundamental and/or applied scientific research under the direction of senior research personnel or faculty.
30% Collects and analyzes basic research data, conducts experiments and interviews, and documents results according to established policies and procedures
10% Conducts literature reviews, prepares reports and materials, and disseminates information to appropriate entities and assists with publications
10% Trains individuals and groups on equipment operations, research protocols, and techniques within a specialized laboratory or research area
30% Assists with the development of research methodologies and procedures
5% Identifies concerns and recommends solutions to leadership
5% Assists in developing grant applications and proposals to secure research funding
10% Operates, cleans, and maintains organization of research equipment and research area. Tracks inventory levels and places replenishment orders
Institutional Statement on Diversity:
Diversity is a source of strength, creativity, and innovation for UW-Madison. We value the contributions of each person and respect the profound ways their identity, culture, background, experience, status, abilities, and opinion enrich the university community. We commit ourselves to the pursuit of excellence in teaching, research, outreach, and diversity as inextricably linked goals.
The University of Wisconsin-Madison fulfills its public mission by creating a welcoming and inclusive community for people from every background - people who as students, faculty, and staff serve Wisconsin and the world.
Required: - 3 or more years of training or professional work experience in a research laboratory involved in mammalian genetics/genomics research. - Training and experience extracting and isolating DNA and RNA from mammalian cells for sequencing as well as preparing and evaluating DNA and RNA sequencing libraries. - Experience with mammalian cell culture - Effective communication, interpersonal, and negotiating skills
Preferred: - Experience with long-read and ultra long-read genome sequencing - Experience with advanced sequencing techniques including single cell and epigenomic analyses - Experience with cytogenetics techniques (e.g., FISH)
Full Time: 100%
It is anticipated this position requires work be performed in-person, onsite, at a designated campus work location.
Appointment Type, Duration:
Minimum $58,000 ANNUAL (12 months) Depending on Qualifications Actual pay will depend on experience and qualifications. Employees in this position can expect to receive benefits such as generous vacation, holidays, and paid time off; competitive insurances and savings accounts; retirement benefits. Benefits information can be found at (https://hr.wisc.edu/benefits/).
Please be aware that successful applicants are responsible for ensuring their continuous eligibility to work in the United States (i.e. a citizen or national of the United States, a lawful permanent resident, a foreign national authorized to work in the United States without the need of employer sponsorship) on or before the effective date of appointment. This position is an ongoing position that will require continuous work eligibility.
How to Apply:
To apply for this position, please click on the "Apply Now" button. You will be asked to upload a current resume/CV and a cover letter briefly describing your qualifications and experience as it relates to this role.
The University of Wisconsin-Madison is an Equal Opportunity and Affirmative Action Employer.
Qualified applicants will receive consideration for employment without regard to, including but not limited to, race, color, religion, sex, sexual orientation, gender identity, national origin, age, pregnancy, disability, or status as a protected veteran and other bases as defined by federal regulations and UW System policies. We promote excellence through diversity and encourage all qualified individuals to apply.
Employment will require a criminal background check. It will also require you and your references to answer questions regarding sexual violence and sexual harassment.
The University of Wisconsin System will not reveal the identities of applicants who request confidentiality in writing, except that the identity of the successful candidate will be released. See Wis. Stat. sec. 19.36(7).
The University of Wisconsin–Madison has been a catalyst for the extraordinary since its founding in 1848. Our students, staff, and faculty partake in world-class education and conduct prolific research that solves real-world problems. Our guiding principle is the Wisconsin Idea, a commitment to outreach that creates a better future for our state, our nation, and the world. We value the contributions of each person and recognize that diversity is a source of strength, creativity, and innovation.