The Department of Pathology and Cell Biology at Columbia University Irving Medical Center seeks a highly qualified and motivated laboratory research scientist for a Staff Associate III position to participate in NIH funded studies on the biology of essential tremor (ET) through study of human post-mortem brain specimens. The candidate will work with a collaborative team of researchers in Dr. Faust?s laboratory at Columbia University and with Dr. Elan Louis at University of Texas Southwestern. Researchers participate in quantitative morphologic analyses in human brain tissue specimens and molecular analyses to map out biological changes in the tremor circuitry that may define disease pathogenesis in ET. In a second project, we are exploring the role of dysregulated ER calcium handling in