Berkeley Lab's (LBNL) Environmental Genomics and Systems Biology (EGSB) Division has an opening for a Postdoctoral Fellow to join in the Deutschbauer Lab as part of the Department of Energy's (DOE) Biopreparedness Research Virtual Environment (BRaVE) initiative.
The BRaVE Phage Foundry is a high-throughput platform for rapid design and development of countermeasures to combat emerging drug-resistant pathogens. This collaborative effort is meant to rapidly develop novel countermeasures against emerging bacterial pathogens.
In this role, you will develop and apply molecular genetic tools (including barcoded transposon mutagenesis and CRISPR-Cas tools) in bacterial pathogens and bacteriophages. You will analyze these datasets to gain new insights into antibiotic resistance, metabolism, phage host range, and phage/antibiotic interactions.
Collaborating with team members, you will implement machine learning approaches to predict the efficacy of phage/antibiotic combinations against specific pathogens and test these predictions under in-vitro conditions and in animal and plant models. To meet these goals, you will collaborate closely with the BRaVE Phage Foundry experimental and computational teams.
This position has an anticipated start date of November 1, 2023.
Perform investigations into microbial gene functions related to phage-bacteria interactions, metabolism, and antibiotic resistance using high-throughput genetic tools.
Collaborate with BRaVE Phage Foundry experimental and computational team members to design experiments so the data developed can be used to predict phage modifications, phage cocktail compositions, and to test the effectiveness of these compositions.
Present data at meetings and conferences
Keep abreast of current scientific literature.
Publish results in peer-reviewed journals.
Participate and provide periodic updates in lab group meetings.
Upon request, report findings to the funding agency.
Ensure all data and models are FAIR (Findable, Accessible, Interoperable and Reusable) and well-documented.
Maintain a comprehensible and trackable laboratory/computational notebook so that the provenance of data and analysis can be tracked.
Ensure accessibility of reports, protocols, presentations, and manuscripts for the larger program.
What is Required:
A recent Ph.D. (within the last 1-2 years) in Molecular Biology, Microbiology, Genetics, or a related field.
Advanced Molecular Biology, Biochemistry, and Microbiology skills.
Experience designing and cloning DNA constructs.
Experience with functional genomic techniques including whole-genome DNA sequencing, transcriptomics, and analysis of Tn-seq data.
Experience analyzing large datasets.
Excellent oral and written communication skills including experience organizing/presenting technical reports and demonstrated success in the publication of high-impact work in internationally recognized peer-reviewed journals.
Demonstrated interpersonal skills including experience collaborating with a diverse interdisciplinary research team.
Experience with programming and using liquid handling robots.
Demonstrated ability to analyze Next-Generation Sequencing (NGS) DNA data.
Working knowledge of R or Python.
Experience culturing bacteria under anaerobic conditions.
For first consideration, please apply with a curriculum vitae (CV) or resume by October 11, 2023.
This is a full time, exempt from overtime pay (monthly paid), 3 year (benefits eligible), Postdoctoral Fellow appointment with the possibility of renewal based upon satisfactory job performance, continuing availability of funds, and ongoing operational needs. You must have less than 2 years of paid postdoctoral experience.
The monthly salary range for this position is $5,643-$6,766 and is expected to start at $5,643 or above. Postdoctoral positions are paid on a step schedule per union contract and salaries are predetermined based on postdoctoral step rates. Each step represents one full year of completed post-Ph.D. postdoctoral and/or related research experience.
This position is represented by a union for collective bargaining purposes.
This position may be subject to a background check. Any convictions will be evaluated to determine if they directly relate to the responsibilities and requirements of the position. Having a conviction history will not automatically disqualify an applicant from being considered for employment.
This position will be performed onsite at either the West Berkeley Biocenter (Potter St.) -- Bldg. 977, 717 Potter St., Berkeley, CA 94710.
Learn About Us:
Berkeley Lab (LBNL) addresses the world's most urgent scientific challenges by advancing sustainable energy, protecting human health, creating new materials, and revealing the origin and fate of the universe. Founded in 1931, Berkeley Lab's scientific expertise has been recognized with 16 Nobel prizes. The University of California manages Berkeley Lab for the U.S. Department of Energy's Office of Science.
Berkeley Lab's Postdoc Program is committed to providing Postdoctoral Researchers and Visiting scholars with a positive and impactful experience to jump-start their career through premium research and career development, networking opportunities, mentoring programs, and a strong community. For more information, please visit our Berkeley Lab Postdoc Resources site and our Berkeley Lab Postdoc Association site.
Berkeley Lab is an Equal Opportunity and Affirmative Action Employer. We heartily welcome applications from women, minorities, veterans, and all who would contribute to the Lab's mission of leading scientific discovery, inclusion, and professionalism. In support of our diverse global community, all qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or protected veteran status.
In the world of science, Lawrence Berkeley National Laboratory (Berkeley Lab) is synonymous with excellence. Thirteen scientists associated with Berkeley Lab have won the Nobel Prize. Fifty-seven Lab scientists are members of the National Academy of Sciences (NAS), one of the highest honors for a scientist in the United States. Thirteen of our scientists have won the National Medal of Science, our nation's highest award for lifetime achievement in fields of scientific research. Eighteen of our engineers have been elected to the National Academy of Engineering, and three of our scientists have been elected into the Institute of Medicine. In addition, Berkeley Lab has trained thousands of university science and engineering students who are advancing technological innovations across the nation and around the world. Berkeley Lab is a member of the national laboratory system supported by the U.S. Department of Energy through its Office of Science. It is managed by the University of California (UC) and is charged with conducting unclassified research across a wide range of scientific disciplines. Located on a 200-acre site in the hills above the UC Berkeley campus that offers spectacular... views of the San Francisco Bay, Berkeley Lab employs approximately 4,200 scientists, engineers, support staff and students. Its budget for 2011 is $735 million, with an additional $101 million in funding from the American Recovery and Reinvestment Act, for a total of $836 million. A recent study estimates the Laboratory's overall economic impact through direct, indirect and induced spending on the nine counties that make up the San Francisco Bay Area to be nearly $700 million annually. The Lab was also responsible for creating 5,600 jobs locally and 12,000 nationally. The overall economic impact on the national economy is estimated at $1.6 billion a year. Technologies developed at Berkeley Lab have generated billions of dollars in revenues, and thousands of jobs. Savings as a result of Berkeley Lab developments in lighting and windows, and other energy-efficient technologies, have also been in the billions of dollars. Berkeley Lab was founded in 1931 by Ernest Orlando Lawrence, a UC Berkeley physicist who won the 1939 Nobel Prize in physics for his invention of the cyclotron, a circular particle accelerator that opened the door to high-energy physics. It was Lawrence's belief that scientific research is best done through teams of individuals with different fields of expertise, working together. His teamwork concept is a Berkeley Lab legacy that continues today.