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The Genome Engineering Core is a new facility with the mission of providing CRISPR-based functional genomics and spatial profiling services to collaborators at Columbia University and beyond. Our functional genomics expertise includes pooled genome-wide and custom-library screens with amplicon-seq and single-cell RNA sequencing readouts. We employ diverse CRISPR technologies, including CRISPR, CRISPRi, and CRISPR base editing. Our spatial profiling service includes a 10X Genomics Xenium next-gen in situ machine. Our goal is to use these cutting-edge technologies in collaborations involving precision medicine, cancer genomics, immunology, and other fields. This position will prepare plasmid and viral libraries, perform cell culture for screens, and operate the Xenium spatial profiling machine. In addition, the position will include general lab management duties. Members of the lab will have opportunities to learn and develop cutting-edge CRISPR technologies.

Responsibilites will include:

50%: Carrying out CRISPR-based functional genomics screens, including making plasmid libraries, lentiviral libraries, and performing screen cell culture.

30%: Performing spatial profiling experiments by operating the Xenium in situ spatial profiler.

20%: General laboratory maintenance needs, including ordering, inventory management, financial management, IT coordination, equipment maintenance and repair, creating and maintaining protocols and lab notebook entries, and piloting new experimental techniques.

• Bachelor's degree in biology, biochemistry, genetics, or related field. 
• 4 years of related work experience preferred.

Columbia University is an Equal Opportunity Employer / Disability / Veteran

Pay Transparency Disclosure

The salary of the finalist selected for this role will be set based on a variety of factors, including but not limited to departmental budgets, qualifications, experience, education, licenses, specialty, and training.  The above hiring range represents the University's good faith and reasonable estimate of the range of possible compensation at the time of posting.

About Columbia University

Columbia University is one of the world's most important centers of research and at the same time a distinctive and distinguished learning environment for undergraduates and graduate students in many scholarly and professional fields. The University recognizes the importance of its location in New York City and seeks to link its research and teaching to the vast resources of a great metropolis. It seeks to attract a diverse and international faculty and student body, to support research and teaching on global issues, and to create academic relationships with many countries and regions. It expects all areas of the university to advance knowledge and learning at the highest level and to convey the products of its efforts to the world.

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