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Posted: 28-Jun-23
Location: St. Louis, Missouri
Type: Full-time
Salary: Open
Internal Number: JR75633
Job Description
Position Summary
A Computational Biology/Bioinformatics position is available in the Mitreva Lab (https://mitrevalab.wustl.edu) at the Division of Infectious Diseases, Department of Medicine and McDonnell Genome Institute and Washington University School of Medicine. The candidate will be part of an established and successful research group focused on integrating â˜multi-omicsâ™ approaches aimed at understanding infectious diseases at a systems biology level. The position requires working collaboratively with a team of experimental and computational biologists focused on integrating multidimensional biological data to better understand pathogen biology, ecology, host-pathogen interaction, population genomics signatures, epidemiology, transmission etc.
The postdoctoral fellow will work on NIH funded projects focused on disease caused by helminth infections. Helminthes are endemic in developing countries and helminth infections are typified by long term chronicity accompanied with various symptoms (pain, malnutrition, physical disabilities, rectal prolapse, deformity), cause growth impairment in children, anemia, adverse outcomes in pregnant women and reduced productivity in adults, which all conspire to promote and maintain poverty. The projects aim at identifying genetic markers and mechanisms of anthelmintic resistance to facilitate production of tools to tackle post-treatment recrudescence of infection, parasites emergence and spread. The candidate will be responsible for leading and carrying out this innovative project that involve population and functional genomics studies of these important parasites and will have opportunities to travel and to present at national and international conferences.
Washington University School of Medicine (https://medicine.wustl.edu) is one of the two main campuses of Washington University in St. Louis (https://wustl.edu), a private research university founded in 1853. Mitreva Lab is housed in the McDonnell Genome Institute (http://genome.wustl.edu/) which has been at the forefront of genome research since its inception in 1993. We are a world-leader in genomics research as it applies to the study of model organisms and human biology, infections, genetic diseases, and the field of personalized medicine. We provide a value-added biologically and clinically relevant sequence analysis, and foster public understanding of science through various educational and outreach efforts.
Publications reflecting the research portfolio of Mitreva Lab:
https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=mitreva+m+or+mitreva-dautova+m
Information on being a postdoc at Washington University in St. Louis can be found at https://postdoc.wustl.edu/prospective-postdocs-2/.
Required Qualifications
- Graduate degree (Ph.D.) in computational biology or a related field.
- Solid background in molecular biology/genetics techniques, computational biology and biostatistics.
Preferred Qualifications
- Ability to be outstanding in drive, eagerness, and scientific imagination, as well as organized and self-motivated.
- Experience in genomics and bioinformatics.
- Experience in computational, statistical analysis and phylogenomics are particularly encouraged.
- Familiarity with frequently used bioinformatic tools (NGS aligners, GATK package, NCBI website tools, Ensembl, UCSC genome browser, Kinship, RNA-seq analysis tools, DEseq).
- Proficient in R and in programming languages (MATLAB, C#, and R), programs useful for high-throughput analysis (e.g. cytoscape), databases (MySQL, Oracle), Perl scripting language.
- Comfortable working on UNIX/Linux platform.
Working Conditions
This position works in a laboratory environment with potential exposure to biological and chemical hazards. The individual must be physically able to wear protective equipment and to provide standard care to research animals.
Salary Range
Base pay is commensurate with experience.
Applicant Special Instructions
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Interested candidates should email cover letter, curriculum vitae, summary of their research, one key first author publication and contact information for three recent references to Dr. Makedonka Mitreva, Ph.D. at mmitreva@wustl.edu.
Accommodation
If you are unable to use our online application system and would like an accommodation, please email CandidateQuestions@wustl.edu or call the dedicated accommodation inquiry number at 314-935-1149 and leave a voicemail with the nature of your request.
Pre-Employment Screening
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.Benefits Statement
Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status, full-time equivalent (FTE) workload, and weekly standard hours. Please visit our website at https://hr.wustl.edu/benefits/ to view a summary of benefits.EEO/AA Statement
Washington University in St. Louis is committed to the principles and practices of equal employment opportunity and especially encourages applications by those from underrepresented groups. It is the Universityâ™s policy to provide equal opportunity and access to persons in all job titles without regard to race, ethnicity, color, national origin, age, religion, sex, sexual orientation, gender identity or expression, disability, protected veteran status, or genetic information.Diversity Statement
Washington University is dedicated to building a diverse community of individuals who are committed to contributing to an inclusive environment â“ fostering respect for all and welcoming individuals from diverse backgrounds, experiences and perspectives. Individuals with a commitment to these values are encouraged to apply.
