The project will create human subject-specific induced pluripotent stem cells from deidentified repository specimens, use these to prepare human neuron cultures, and test the effect of alcohol treatment on gene expression, neuronal development, and neurophysiology. Gene editing and/or gene variant selection will incorporate human genetic information linked with alcohol abuset. The goal is to identify neuronal mechanisms underlying alcohol usage disorders.
Minimum Education and Experience:
A Ph.D. and at least one year of relevant postdoctoral research experience is required. The successful candidate will have demonstrated experience in culture of human induced pluripotent stem cells and differentiation of these cells into electrophysiologically mature neurons. Experience in electrophyiology is required. Evidence of experience is first-author (or equivalent) publication in peer-reviewed research journals. Due to the highly collaborative nature of this project, excellent communication skills are required, as evidenced by authorship of first-author research journal articles and references from tenured faculty attesting to oral communication skills and ability to interact with other scientists.
The project requires usage of BSL2 biosafety cabinets, fluorescent microscopy, electrophysiology equipment, and general molecular biology lab equipment (centrifuges, thermal cyclers, micropipets, etc.).
Physical Demands and Work Environment:
The candidate must have sufficient manual dexterity to operate micropipets, fluorescent microscopes, and related equipment. The candidate must be cabable of working in a BSL2 biosafety cabinet for extended periods.
Rutgers, The State University of New Jersey, is a leading national public research university and the state's preeminent, comprehensive public institution of higher education. Rutgers is dedicated to teaching that meets the highest standards of excellence; to conducting research that breaks new ground; and to turning knowledge into solutions for local, national, and global communities. As it was at our founding in 1766, the heart of our mission is preparing students to become productive members of society and good citizens of the world. Rutgers teaches across the full educational spectrum: preschool to precollege; undergraduate to graduate and postdoctoral; and continuing education for professional and personal advancement. Rutgers is New Jersey's land-grant institution and one of the nation's foremost research universities, and as such, we educate, make discoveries, serve as an engine of economic growth, and generate ideas for improving people's lives.