The research associate will conduct research to determine the cryo-electron microscopic structure of a protein-DNA complex formed in the process of replication initiation using Escherichia coli as a model system (https://bmb.natsci.msu.edu/faculty/jon-m-kaguni/current-research/). The individual will also obtain training in nucleic acid enzymology and molecular genetics.
Detailed description of work/duties: The research associate will perform experiments to assemble and analyze a protein-DNA complex using established biochemical assays. The individual will also learn about isolating the complex by several methods, and visualizing the complex by transmission electron microscopy and cryo-electron microscopy. The postdoc is expected to participate in seminars, journal clubs, weekly lab meetings, and manuscript preparation.
Equal Employment Opportunity Statement
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, citizenship, age, disability or protected veteran status.
Applicants should have received a Ph.D. in biochemistry, structural biology, molecular biology, biophysics, chemistry or related science field within the last five years and should have extensive experience in protein purification and biochemical characterization. The candidate should have excellent communication skills, and be comfortable working collaboratively with other lab members.
Applicants should have received a Ph.D. in biochemistry, structural biology, chemistry or related science field within the last five years.
Expertise in nucleic acids, protein biochemistry, and recombinant DNA techniques is highly desirable.
Required Application Materials
Qualified applicants should submit a CV, a cover letter summarizing research experience and research interests, and the names and contact information of three professional references.
In addition to sending the required application materials through the MSU Human Resources portal, please also send the application package by email to Dr. Jon M. Kaguni (email@example.com).
The position is available immediately and is for one year with the possibility of extension depending on available funds.
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