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Posted: 27-May-23
Location: Ann Arbor, Michigan
Salary: Open
Internal Number: 230792
In addition to applying for this position online, Interested candidates should contact Dr. Santhi Ganesh, Division of Cardiovascular Medicine, Department of Internal Medicine, with current resume or CV and references. Email: sganesh@umich.edu Lab website: www.ganeshlab.org
The Ganesh lab is seeking a talented Postdoctoral Research Fellow for genetic and molecular studies of vascular disease in the context of Neurofibromatosis type I, vascular connective tissue diseases, and related disorders leading to adverse arterial remodeling, stenosis, and hypertension. The ideal candidate for this position has experience with in vitro and/or in vivo models of disease; the projects rely on existing and future murine and cell line models for disease, in addition to transcriptomc and protein translation studies.
We are conducting gene discovery studies using genome sequencing, GWAS and transcript expression profiling methods to understand both common and rare vascular diseases. We are generating epigenetic data sets for integrative genomic studies. In the wet lab side of the laboratory, we use in vitro cellular and in vivo models to assess the functional significance of our genomic discoveries. This will provide an opportunity for collaboration with functionally oriented lab personnel and trainees. Our studies are closely tied to the clinic, with human tissue and blood samples from meticulously phenotyped patients and thus candidates can expect to gain exposure to translational aspects of their research projects as well. This is an opportunity to join a dynamic laboratory that is using genetic and genomic discovery approaches to study novel influences on disease, using both dry-lab and wet-lab approaches.
Our projects include gene discovery approaches such as genome sequencing, and functional experimentation to understand mechanisms of discovered genes using in vitro and in vivo murine models. Candidates should have experience and/or publications in genetics, molecular biology, vascular biology, or computational biology/transcriptomics areas, with an interest in human genetics. This is an excellent opportunity for individuals interested in both human genetics and functional biology investigations, and, to see how the two are integrated in disease-oriented research.
The laboratory has secured multiple NIH and non-NIH sources of funding. Dr. Ganesh is a faculty mentor of several NIH-supported T32 training grants at University of Michigan. There is a current opportunity for NIH training grant support and if interested, please get in touch soon to discuss.
- M.D. or Ph.D. required.
- Basic science discipline preferred, such as molecular biology, cell biology, or vascular biology.
- Candidates with computational skills are also encouraged to apply.
- The ideal candidate is highly motivated to learn conduct cellular and molecular studies to inform human diseases, scientific methods, and write manuscripts and grant applications.
40 hours, full-time. Days -- hours negotiable.
Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings. Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.
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Job openings are posted for a minimum of seven calendar days. The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.
The University of Michigan is an equal opportunity/affirmative action employer.
