This post-doctoral position will be part of a team effort to investigate HIV-induced vascular dysfunction and neuroAIDS molecular mechanisms using in vitro and in vivo (animal models) approaches. Specifically, the person will utilize HIV mouse models and HIV-1 infected cellular models to conduct experiments investigating the molecular events associated with cellular and vascular dysfunction in neuroAIDS. These studies will involve advanced molecular biology, including single cell transcriptomics, genomics and epigenomics, data analysis and interpretation. Additional molecular and cell biology techniques include molecular cloning, gene transfection and expression, siRNA technology, qPCR, FACS analysis, confocal imaging, histology, immunohistochemistry, immunofluorescence, ELISA, Western blots, and other protein chemistry techniques. The ideal candidate will be creative, highly motivated and have significant experience in these molecular and cell biology techniques; and preferably experience working with laboratory animals, including animal injection, collection and processing of animal tissues and biological fluids; and analyses of these samples. The candidate should be able to design and perform experiments with minimal supervision, critically analyze the results, summarize, present, and discuss the results with other team members, and help write manuscripts for publications.
Ability to perform in vivo experiments with mice (including drug treatment / injection, blood collection, tissue harvesting, downstream analyses of blood and tissues); experience in molecular biology, single cell transcriptomics, genomics, and/or epigenomics analyses.
A vital enterprise in the nation’s heartland, the University of Nebraska Medical Center has its eye on improving the future of health care in Nebraska and beyond. As Nebraska’s only public academic health sciences center, UNMC is committed to the education of a 21st century health care work force, to finding cures and treatments for devastating diseases, to providing the best care for patients, and to serving our state and its communities through award-winning outreach. UNMC also is committed to embracing the richness of diversity, and is a major economic engine for the state of Nebraska. Led by Chancellor Jeffrey P. Gold, M.D., UNMC has six colleges, two institutes and a graduate studies program, serving nearly 4,000 students in more than two dozen programs. Our physician assistant program was recently ranked ninth in the nation by U.S. News & World Report, and our primary care program was ranked 17. The university’s physical therapy, pharmacy and public health programs also are ranked among the top in the country.
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