The laboratory of Philip Spanheimer, MD at the University of North Carolina at Chapel Hill and the Lineberger Comprehensive Cancer Center is inviting applications for two funded positions to begin as early as April 2021. The Spanheimer lab studies mechanisms of transcriptional regulation associated with patterns of gene expression related to key phenotypic traits. Particular areas of emphasis are investigating how the program of estrogen response is maintained in estrogen receptor positive breast cancer and identifying novel therapeutic vulnerabilities in tumors that become unresponsive to antiestrogen treatment (Spanheimer et al. Clin Cancer Research 2014, Spanheimer et al. Ann Surg 2014, Spanheimer et al. Ann Surg Oncol 2015). We work with cell line and in vitro models, but as a surgeon we also have direct use of fresh human tumor specimens. We are developing novel experimental approaches with fresh cancer specimens using single cell sequencing. We use techniques such as chromatin immunoprecipitation sequencing, affinity purification mass spectroscopy, and genetic manipulations with siRNA to study effects of transcription factors on gene expression and transcription factor interactions. We work very closely and are physically next to the Chuck Perou lab.
Education and Experience:
The ideal candidate will be highly motivated to join a vibrant research laboratory to take advantage of sophisticated model systems that we have developed. Candidates with prior experience in molecular biology, molecular genetics, cancer genomics, and/or computational biology will be preferred.
Carolina rates among the nation’s great institutions of higher education, set on an historic and beautiful campus that celebrates all four seasons. Carolina’s students, faculty and staff come here from around the world, bringing varied cultural, racial and ethnic heritages that help make UNC-Chapel Hill a thriving intellectual center. We’re repeatedly ranked the nation’s best value in higher education for students seeking to earn a college degree – the University has garnered the top spot each time since the ranking’s launch in 1998.Whether you’ve just started your career, are new to academia or are a seasoned professional with assorted campus experiences to draw on, we hope you will find a great place at Carolina.