The focus of the research for the position is on the development of novel therapeutics to extend healthspan.Â The Robbins laboratory is part of a U19 grant identifying rare variants in centenarians linked to longevity.Â The role of these rare variants in conferring healthspan and longevity is being validated in mouse models.Â Subsequently, cell culture assays will be developed by the candidate for screening for compounds able to mimic the effect of the rare variant on key signaling pathway. The lead molecules will then be tested in animal models of aging for ability to extend healthspan.Â Â Â
Required Qualifications: -PhD in Biochemistry or a related area with specialization in cell signaling pathways, cell culture and experience working with mice. -Experience conducting a large research project involving several smaller projects and coordinate the analysis, evaluation, and report on progress. This includes developing research plans and applying the appropriate methodology. -Experience managing the financial and budgetary aspects of research project. -Experience serving as an expert resource to lab members, outside collaborators, and the scientific community working on senescence, mitochondrial function and other hallmarks of aging in cell culture and in mice. -Experience of successfully directing a small research group and contributing to writing papers and grants.
Preferred Qualifications: Skilled in molecular biology, mammalian cell culture, confocal imaging, bioinformatics and rodent experimentation. Good verbal and written communication skills, the ability to work independently, and an interest in mentoring young scientists.
Essential and Other Functions:
80%Laboratory Research (essential) Cell culture, microscopy, immunoblotting, qPCR, cloning, drug development, experimental design, data analysis and recording primary data and methods used.
10%Research communication (essential) Critical analysis of the literature, preparing manuscripts, oral presentations and posters.
10%Mentoring (secondary) Training graduate, undergraduate and technical staff in theoretical and/or bench science
Summary of Robbins lab research: A research position is available in the laboratory of Dr. Paul Robbins. His research program is focused on discovering fundamental mechanisms of aging. His laboratory employs a combination of genetic and pharmacologic approaches to test hypotheses about the causes of aging using murine models and primary cell populations derived from them. The laboratory is using genetic analysis of human centenarians to identify pathways important for extending human healthspan.Â The candidate will be developing drugs targeting these pathways are being developed and tested. The candidate will join an exciting research environment in the Department of Biochemistry, Molecular Biology and Biophysics and the newly established Institute on the Biology of Aging and Metabolism at University of Minnesota. The position offers exceptional training in aging, age-related diseases, cellular senescence, DNA damage and repair and molecular therapeutics.
The University of Minnesota, founded in the belief that all people are enriched by understanding, is dedicated to the advancement of learning and the search for truth; to the sharing of this knowledge through education for a diverse community; and to the application of this knowledge to benefit the people of the state, the nation, and the world.