The Post Doctoral Scholar will pursue specialized research training and experience under the guidance of a scientific mentor, Dr. Gang Xin within the Comprehensive Cancer Center at the Ohio State University.
Dr. Xins laboratory focuses on understanding the mechanisms underlying resistance to cancer immunotherapy. Despite the revolutionary success of immunotherapies such as immune checkpoint-blocking (ICB) antibodies, only a small fraction of patients respond to these therapies owing to dysfunctional T cells and immunosuppressive myeloid cells in the tumor.
To improve T cell function, our lab will employ cutting edge single-cell sequencing and bioinformatic analysis to identify a novel transcriptional mechanism of T cells exhaustion. Furthermore, we will also explore how the metabolic crosstalk between cancer cells and tumor-infiltrating myeloid cells shapes their inhibitory function against T cells. Ultimately, our goal is to exploit this knowledge to develop novel therapeutic strategies to broaden and boost the efficacy of cancer immunotherapy. We are seeking candidates with immunology background.
Key Responsibilities may include:
Conduct research to characterize the genetic basis of human cancers
Develop, adopt and implement new laboratory methods to achieve characterization of the genetic basis of human cancers
Identify novel genes and examines their role in cancer development
Analyze changes in gene copy number and mRNA or protein expression, gene cloning, and mutation detection
Participate in analyzing data for reports for the purpose of grants submissions
Train staff in molecular biology techniques
Minimum Education Required:
A Doctoral degree in an appropriate discipline is required.
Requires successful completion of a background check
Qualified candidates may be asked to complete a pre-employment physical including a drug screen
The Ohio State University is a dynamic community of diverse resources, where opportunity thrives and where individuals transform themselves and the world. The Ohio State University is one of the nations largest and most comprehensive public universities and a top employer in Ohio.
As one of only 50 designated comprehensive cancer centers in the nation, The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute is dedicated to the creation of knowledge in laboratory, clinical and population-based cancer research. We apply those discoveries to develop more effective approaches to cancer prevention, diagnosis, and therapies providing tomorrows standard of care today. A Cancer-Free World Begins Here.
The OSUCCC James is the only cancer program in the United States that features a National Cancer Institute (NCI)-designated comprehensive cancer center aligned with a nationally ranked academic medical center and a freestanding cancer hospital on the campus of one of the nations largest public universities. is the only cancer program in the United States that features a National Cancer Institute (NCI)-designated comprehensive cancer center aligned with a nationally ranked academic medical center and a freestanding cancer hospital on the campus of one of the nations largest public universities.
As an Ohio State employee, you will also have access to many benefits such as
Retirement Package choice of OPERS or Alternative Retirement Plan
Competitive Vacation and Sick Leave Program
11 Paid Holidays per year
Dental and Vision Insurance
Opportunity to purchase season tickets to OSU sporting events
Additional discounted rates on things such as select cell phone plans, pet care, food and dining, etc.
The Target Hiring Range is $54,840.00 to $66,600.00. (per NIH guidelines for 2022)
The Ohio State University is a dynamic community of diverse resources, where opportunity thrives and where individuals transform themselves and the world. Founded in 1870, Ohio State is a world-class public research university and the leading comprehensive teaching and research institution in the state of Ohio. With more than 63,000 students (including 57,000 in Columbus), the Wexner Medical Center, 14 colleges, 80 centers and 175 majors, the university offers its students tremendous breadth and depth of opportunity in the liberal arts, the sciences and the professions.