The Brahma Lab is seeking highly motivated postdoctoral candidates with a strong interest in chromatin biology to join our team. We have fully funded positions available immediately for both wet-lab and computational biologists to obtain postdoctoral training in the broad areas of chromatin dynamics and transcription regulation.
Our lab is dedicated to understanding how the landscape of genomic nucleosomes and genome access is regulated in both normal cellular development and cancer. A major focus is on elucidating the mechanisms of ATP-dependent chromatin remodeling and unraveling the intricate interplay between chromatin remodelers and transcription factors in regulating chromatin structure and gene expression. We have several ongoing projects aimed at solving the chromatin structure of genes at distinct stages of transcription, determining how ATP-dependent nucleosome remodeling modifies chromatin structure and modulates the interaction of transcription factors with chromatin, and identifying how defective chromatin remodelers drive disease gene expression patterns. To achieve our research objectives, we take a highly interdisciplinary approach utilizing cutting-edge techniques in structural and functional epigenomics, biochemistry, bioinformatics, and microscopy.
PhD or MD/PhD degree in the fields of Genomics, Molecular Biology, Biochemistry, Cancer Biology, or a related discipline.
The candidate should have evidence of prior productive scientific work in the form of publications in peer-reviewed journals. Previous working experience with chromatin biology and epigenetics/epigenomics research, next-generation sequencing technologies, and bioinformatics is preferred but not compulsory.
A vital enterprise in the nation’s heartland, the University of Nebraska Medical Center has its eye on improving the future of health care in Nebraska and beyond. As Nebraska’s only public academic health sciences center, UNMC is committed to the education of a 21st century health care work force, to finding cures and treatments for devastating diseases, to providing the best care for patients, and to serving our state and its communities through award-winning outreach. UNMC also is committed to embracing the richness of diversity, and is a major economic engine for the state of Nebraska. Led by Chancellor Jeffrey P. Gold, M.D., UNMC has six colleges, two institutes and a graduate studies program, serving nearly 4,000 students in more than two dozen programs. Our physician assistant program was recently ranked ninth in the nation by U.S. News & World Report, and our primary care program was ranked 17. The university’s physical therapy, pharmacy and public health programs also are ranked among the top in the country.
Read more about how this public academic health sciences center helps Nebraska.