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Details
Posted: 16-Apr-23
Location: Irvine, California
Type: Full-time
Salary: Open
Internal Number: 4102683
University of California Irvine
Multi-omics Postdoctoral Fellowship - Ng Lab
A postdoctoral position is available at the University of California, Irvine under the leadership of Dr. Stanley Ng. The successful candidate will explore the relationship between the hierarchy of molecular layers from epigenome to phenome at clonal resolution in various tissues. In brief, studies will involve the generation of multiple data modalities from human and mouse tissue clones, including spatially-resolved somatic DNA mutations, gene and protein expression, and methylation profiles. Bioinformatic integration of distinct data types and subsequent statistical analyses will be performed to elucidate how alterations to various molecular layers in individual clones can lead to their respective contributions to disease development/progression, malignant transformation, and treatment-specific resistance. Thus, these studies will facilitate the identification of novel risk markers and therapeutic targets. The development of minimally-invasive and clinically-relevant biofluid-based molecular risk and treatment response predictors using statistical models will also be investigated, with the goal of clinical translation.
We are seeking candidates who are interested in developing novel diagnostic tools and identifying tailored disease-clone specific targeting strategies. Successful candidates will be expected to work independently, while collaborating with bioinformaticians, biologists, clinicians, and other scientists as appropriate to achieve scientific aims.
Our lab employs bleeding-edge computational platforms and state-of-the-art omics technologies. UC Irvine is a world-class research university with highly ranked graduate programs in biomedical sciences. Our Southern California location is home to one of the largest academic research and biotechnology hubs in the US. Lab members enjoy direct access to this outstanding community of clinicians and scientists, as well as the wide range of recreational activities available in our region. Successful candidates will join an interdisciplinary and highly collaborative team working to develop the next generation of tools and technologies to advance precision diagnostics and therapeutics.
Required Qualification
Preferred Skills/Qualifications
Salary will be based on University of California guidelines for Postdoctoral scholars and is commensurate with qualifications and experience. Appointments will be for up to 3 years, and will be funded by extramural awards.
For additional information about the research program and this opportunity, please contact Dr. Ng at stanlewn@uci.edu.
To apply, visit https://recruit.ap.uci.edu/JPF08190
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Since 1965, the University of California, Irvine has combined the strengths of a major research university with the bounty of an incomparable Southern California location. UCI's unyielding commitment to rigorous academics, cutting-edge research, and leadership and character development makes the campus a driving force for innovation and discovery that serves our local, national and global communities.
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