Postdoctoral Research Associate - Pulmonary & Critical Care Medicine
Washington University in St. Louis
Location: St. Louis, Missouri
Internal Number: JR73972
We are an NIH-funded laboratory in the Division of Pulmonary and Critical Care Medicine at Washington University. The overarching goal of our research program is to determine how epithelial cell-derived proteins can be harnessed to mitigate the risk of acute lung injury in various settings, to ultimately reduce the burden of end-stage lung disease. We have active projects investigating lung injury due to bacterial infections (such as Pseudomonas aeruginosa ), and the short- and long-term consequences of ischemia-reperfusion injury occurring in the context of lung transplantation. We utilize state-of-the-art technical modalities including high-throughput screening, multiparameter flow cytometry, protein and DNA-based molecular biology, biochemistry, cell/tissue culture, fluorescence and confocal microscopy, and DNA/RNA sequencing. Additionally, we draw upon a robust biorepository of lung tissue, bronchoalveolar lavage fluid and DNA from patients to guide and validate our research. Recent work includes:
Ma et al. Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection. Sci Immunol 2021.
Scozzi et al. Circulating mitochondrial DNA is an early indicator of severe illness and mortality from COVID-19. JCI Insight 2021.
Sahu et al. Emerging roles of the complement system in host-pathogen interactions. Trends Microbiol 2022.
Sahu et al. Lung epithelial cell-derived C3 protects against pneumonia-induced lung injury. Sci Immunol 2023.
Prior expertise in molecular and cell biology, and/or bioinformatics will be helpful. This would be a good opportunity for someone with such prior experience to learn more immunology and strengthen concepts in bioinformatics, thereby training from a mentored position towards an independent position in academics, industry, or administration.
Ph.D., M.D. or equivalent terminal or doctoral degree.
This position works in a laboratory environment with potential exposure to biological and chemical hazards.Â The individual must be physically able to wear protective equipment and to provide standard care to research animals.
Base pay is commensurate with experience.
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Washington University in St. Louis, a medium-sized, independent university, is dedicated to challenging its faculty and students alike to seek new knowledge and greater understanding of an ever-changing, multicultural world. The University offers more than 90 programs and almost 1,500 courses leading to bachelor's, master's and doctoral degrees in a broad spectrum of traditional and interdisciplinary fields, with additional opportunities for minor concentrations and individualized programs. The faculty is composed of scholars, scientists, artists and members of the learned professions. They serve society by teaching; by adding to the store of human art, creativity, understanding, and wisdom; and by providing direct services, such as health care.