The Research Scientist will play key roles in identifying research problems and developing research methodologies and procedures, implementing in vitro and in vivo experiments and training students.
SMPH is committed to being a diverse, equitable, inclusive and anti-racist workplace and is an Equal Employment Opportunity, Affirmative Action employer. Applications from Black, Indigenous and People of Color (BIPOC) individuals, LGBTQ+ and non-binary identities, women, persons with disabilities, military service members and veterans are strongly encouraged.
|Responsibilities: ||Scientist I (RE043) |
Scientist II (RE044)
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Ph.D. in the biochemical sciences with an emphasis on either biochemistry, cell biology, immunology, genetics, or closely related field required.
- 3 years minimum of post-doctoral research experience in molecular biology, biochemistry, cell biology, genetics, or immunology in an academic or similar research environment is required.
- Expertise in two or more of following skills/techniques is required:
* Pancreas biology: Islet isolation, human islet culturing and experimenting, islet histomorphometry.
* Mammalian cell culture: siRNA, transfection, stable cell line generation, gene manipulations with CRISPR/Cas9.
* Experience with basic molecular biology and biochemistry methods including, isolation RNA and protein from tissues and cells, qPCR and Western Blot, ChIP, ELISA, microscopy and cloning,
* Immunology: Multicolor FACS analysis, FlowJo analysis, adoptive transfers.
* Prior experience on working with mouse models: Colony management, drug administration (via i.p, sub-Q, i.g injections or via oral gavage), and dissection of the organs.
* Experience with AAV vectors, transduction or mouse injection
* Prior experience on handling large data sets and bioinformatic analysis: single cell RNAseq, scATACseq etc.
- Experience working with transgenic mouse colonies is highly desired.
- Previous experience in cellular signaling/signal transduction, organelle biology, disease mechanisms and metabolism is highly desired. However, candidates trained in other fields such as molecular biology, biochemistry, bioinformatics, cell biology, genetics or immunology with translatable skills will also be considered.
Full Time: 100%
It is anticipated this position requires work be performed in-person, onsite, at a designated campus work location.
Appointment Type, Duration:
Minimum $54,000 ANNUAL (12 months)
Depending on Qualifications
Actual pay will depend on research project experience and qualifications.
Applicants for this position will be considered for the titles listed in this posting. The title is determined by the experience and qualifications of the finalist.
The Engin Laboratory is focused on understanding how cellular stress response and organelle dysfunction plays a role in beta cell physiology and pathology. Current projects involve studying molecular mechanisms of cellular stress responses in pancreatic beta cells in autoimmune diabetes, ER-mitochondria communication, lysosome dysfunction, cellular senescence and the crosstalk between stressed beta cells and immune cells. The work involves working with the beta cell or immune cell-specific mouse models of the unfolded protein response pathway and mechanistic studies using cell culture (primary mouse and human islets), biochemical and immunological assays (Engin et al., Sci Transl Med 2013, Lee et al, Cell Metab 2020, Chen, et al., Nat Comm 2022). More information about our research and publications can be found at enginlab.org.
Candidates should have demonstrated ability to work effectively in a collaborative manner with faculty and staff, as well as other institutional representatives; strong organizational, written, and verbal communication skills in English; high levels of critical thinking, excellent technical skills, and a strong track-record of accomplishment and productivity in research as evidenced by high-quality publications related to physiology, immunology, metabolism, cell signaling/signal transduction and disease mechanisms.
The successful applicant will be responsible for ensuring eligibility for employment in the United States on or before the effective date of the appointment. University sponsorship is not available for this position.
How to Apply:
To apply for this position, please click on the "Apply Now" button. You will be asked to upload a current resume/CV and a cover letter with a short description of your previous research and why you consider you are a good match for the position. You will also be asked to provide contact information for three (3) references, including your current/most recent supervisor during the application process. References will not be contacted without prior notice.
Relay Access (WTRS): 7-1-1. See RELAY_SERVICE for further information.