St. Petersburg, Florida
Northern & Central California, California
Cambridge, Massachusetts
Work Remote,
New York, New York
New Orleans, Louisiana
Berkeley, California
Posted: 08-Apr-23
Location: La Jolla, California
Salary: Open
Internal Number: 122483
UCSD Layoff from Career Appointment: Apply by 4/11/2023 for consideration with preference for rehire. All layoff applicants should contact their Employment Advisor.
Special Selection Applicants: Apply by 4/20/2023 Eligible Special Selection clients should contact their Disability Counselor for assistance.
DESCRIPTION
The mission of the UCSD Center for Epigenomics is to develop a quantitative and molecular framework to study the function and regulation of the human genome, with the ultimate goal to understand the molecular basis of cancer and other human diseases. Epigenomics is at the forefront of Precision Medicine. The epigenome, a term referring to the state of DNA methylation and the covalent modifications of histone proteins in a cell, plays a central role in regulating the functional output of the genome during development. Changes in the epigenome that result from exposure to stress, pathogenic conditions and during aging can determine the patterns of gene expression and predispose an individual to diseases. Epigenome research promises to significantly improve our understanding of the factors that drive human development and disease. The UCSD Center for Epigenomics works with researchers on the UCSD campus and beyond to foster the application of epigenomic concepts and technologies to clinical, translational, and basic research.
Under the general supervision of the Center for Epigenomics' Associate Director, the Senior Epigenomics Research Associate will independently engage in research projects by designing and performing experiments to map cells' transcriptomes and epigenomes such as ATAC-seq, ChIP-seq, CUT&RUN, scATAC-seq, scRNA-seq, scMultiome, and Paired-Tag.
The incumbent will act as the primary driver for multiple collaborative research projects by implementing new workflows and standard operating procedures across novel and difficult sample types including tissues from atypical model organisms and precious clinical samples such as tissue biopsies. The incumbent will interpret the results to further optimize and scale these workflows. The incumbent will also play a key role in technology development by automating these workflows where appropriate on liquid handling robots to maximize throughput and minimize cost per sample.
The incumbent will independently design experiments and be responsible for careful record keeping, operating laboratory equipment including the Beckman Biomek i7 liquid handler, troubleshooting, quality control, and preparing complete written reports potentially resulting in publications. Additional duties may include contributing to laboratory management, organization of laboratory reagents, and maintenance of laboratory equipment. We seek a candidate who is enthusiastic about learning cutting-edge genomic techniques and working in a dynamic
