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ABOUT THE WINER LAB

The Winer lab at the Buck Institute is interested in studying how the immune system influences chronic inflammation during aging and age-related disease. We are looking for an independent and highly motivated recent PhD, MD, or MD/PhD graduate with a strong background in immunology or cell biology, to study mechanisms of inflammation with age using mouse and cell culture models.

POSITION SUMMARY

The Winer lab at the Buck Institute studies how the immune system influences chronic inflammation during insulin resistance, which occurs in settings of metabolic syndrome and aging (see sample lab papers: Tsai et al Cell Metab 2018, 922-34; Ghazarian et al Science Immunol 2017, Apr 21; Winer et al Cell Metab 2016, 413-26; Luck et al Cell Metab 2015, 527-42; Winer et al Nature Med 2011, 610-7; Winer et al Nature Med 2009; 921-9).  We also have an interest in mechanoimmunology (Du et Nat Rev Immunol 2023; Charkraborty et al Cell Rep 2021). We use immunology, molecular biology, including multi-omic assays, endocrinology, mouse models, and tissue culture assays to elucidate mechanisms by which immune cells and immune molecules influence inflammation in tissues.

The selected applicant will have the opportunity to contribute to several projects, including:

• The immune system in obesity and insulin resistance.
• The immune system in aging and neurodegenerative disease.
• The impact of mechanical forces on immune and other cells.

• PhD, MD, or MD/PhD graduate with a strong background in immunology or molecular biology.
• Prior experience in immunological and molecular assays including immune cell culture assays, flow cytometry, Q-PCR, Western blotting, and ELISA is desirable, in addition to experience with mouse handling.
• Previous work in bioinformatics of RNA sequencing datasets and organoid culture work is especially desirable. 
• Ambitious, independent, and hard-working.
• Will work on a high impact project plus have creative freedom to pursue your own ideas. 

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About Buck Institute for Research on Aging

Our success will ultimately change healthcare. At the Buck, we aim to end the threat of age-related diseases for this and future generations by bringing together the most capable and passionate scientists from a broad range of disciplines to identify and impede the ways in which we age. We are an independent, nonprofit institution located in Marin County, CA, with the goal of increasing human healthspan, or the healthy years of life. Globally recognized as the pioneer and leader in efforts to target aging—the number one risk factor for diseases including Alzheimer’s, Parkinson’s, cancer, macular degeneration, heart disease, and diabetes—the Buck seeks to help people live better longer. We are an equal opportunity employer and strive to create an atmosphere where diversity of identity, experience, and background are welcomed, valued, and supported. Candidates who contribute to this diversity are strongly encouraged to apply.

Connections working at Buck Institute for Research on Aging

https://careers.ashg.org/jobs/18410602/postdoctoral-researcher-in-immunology-and-chronic-diseases-of-aging-winer-lab