Cambridge, Massachusetts
New York, New York
Boston, Massachusetts
Los Angeles, California
Seattle, Washington
Portland, Oregon
Posted: 25-Mar-23
Location: Boston, Massachusetts
Salary: Open
Internal Number: 2023-33793
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world-renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.
The Fischer Lab (https://fischerlab.dana-farber.org/) at Dana-Farber Cancer Institute is a Structural and Chemical Biology Lab that combines molecular biology, computational biology, structural biology and chemistry with various ???Omics??? techniques to study the pathways and protein complexes involved in the regulation of protein homeostasis often associated with human diseases, including cancer. Using our knowledge of the cellular degradation machinery, we use structure and computational guided approaches to develop new molecules that hijack the ubiquitin proteasome system for targeted protein degradation. These molecules are screened using unbiased global proteomics methodology to identify and map targets.
The Fischer Lab seeks a highly motivated individual to join the team as an Associate Computational Biologist. The successful applicant will work closely with the proteomics group to apply computational algorithms to integrate and analyze internal proteomics data with other large scale biological profiling data sources.?? This position involves building data processing pipelines, data integration and data visualization tools for efficiently navigating large amounts of cellular proteomics profiles under various perturbations including chemical perturbation to unveil insights regarding biomolecular interactions.
This is an excellent opportunity to work in a vibrant environment and to apply state of art computational methods to support cutting edge biological research both within the lab and the Dana-Farber Cancer Institute as well as through collaboration with external laboratories and industry.
- Builds data processing pipelines to convert raw data into formats compatible with conventional statistical analysis and identifies and implements appropriate visualization.
- Works with lab personnel to implement automated processing solutions for repeated manual tasks.
- Develops workflows, and databases for analyzing and manipulating proteomics data.
- Collaborates with research personnel to download, organize and integrate various types of experimental and public data into databases.
- Collaborates with laboratory and computational personnel to leverage data to explore trends in cellular responses to perturbations.
- Adheres to best practices for coding and data analysis.
- Aids in preparation of tables and figures for manuscripts and grant proposals
- Bachelor???s degree in Bioinformatics, Computer Sciences or STEM-related field required.
- Master???s degree in Bioinformatics, Computer Sciences or related field is preferred.
- Desire to work in a fast-paced, multidisciplinary research environment
- Knowledge of UNIX/Linux. Familiarity with scripting in Python and statistical programming using R.
- Familiarity with principles of experimental design and the modern data analysis paradigms is required.
- Has some understanding of statistics and different statistical packages used for gene/protein expression analysis.
- Able to discuss and present results, share ideas accurately and communicate them effectively, both in writing and verbally with supervisory oversight.
- Strong teamwork and communication abilities and desire to interact with researchers from a diverse range of skillsets.
Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.
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