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The Department of Pathology and Cell Biology at Columbia University Irvine Medica Center seeks a highly qualified cancer biologist to support the study of the biology of breast cancer health disparities. These NIH-funded research programs implement an integrated focus on multiple different tissue-based biomarkers using digital and computational pathology to analyze 4 independent breast cancer cohorts complete with clinicopathological information. The focus will be on the use of digital pathology to characterize patient tissue samples using quantitative biomarker profiling, genomics, and morphology-based analysis of intrinsic tumor biological features in the tumor immune microenvironment utilizing quantitative immunohistochemistry-based proteomics, multiplex-immunofluorescence, deep-learning and artificial intelligence profiling of breast cancer morphological tissue features, single-cell based spatial gene expression analysis using in situ RNA hybridization, protein-complex profiling utilizing proximity ligation assays, RNA-seq based gene expression,  whole exome sequencing-based mutational profiling, and epigenetic profilings of the patient tissue samples. 

At CUIMC, we stand together because diverse experiences, perspective, and values enrich every dimension of our work. Join our team and see how your unique skills and experiences can create a real impact by changing lives.

Lab Mission:

The position will emphasize investigating the biology underlying the differences in disease occurrence and outcome in breast cancer and how it is influenced by race, ethnicity, and genetic ancestry. 

Job Function:

• Experience in biostatistics and/or bioinformatics or other methods/approaches in computational biology of biomarking profiling and survival curve analysis, basic interpretation of clinicopathological data
• Strong desire to work on fundamental translational research questions in cancer biology, including gene regulation, chromatin biology, and their influence on the tumor microenvironment. 
• A background in immunology is desirable but not required. 
• History of an ability to independently drive a project forward in a team-based interactive environment
• Willingness to provide mentorship to junior lab members are highly desirable.  
• Cell based assays in mammalian cells( proliferations, growth, death, apoptosis, senesence
• Recombinant DNA technology
• Mammalian tissue culture
• Western blotting
• Immunoprecipitation assays
• Cellular transformation assays.
• Immunohistochemistry

Minimum Skills Required:

• Cell based assays, mammalian (growth, death, apoptosis, senesence
• Recombinant DNA technology
• Mammalian tissue culture
• Western blotting
• Cellular transformation assays.
• Excel spreadsheet based simple graphing and MYSQL database analysis.

Minimum Education Requirements:

• Ph.D.  or M.D. equivalent in areas of biochemistry, cancer biology, cell & molecular biology, or related field.

Preferred Qualifications:

• Programing in R
• Programing in Python
• Programing in Matlab
• Experience in Immunology
• Familiarity with Halo Software
• Familiarity with  Visiopharm Software
• Familiarity with Leica Image Scope Software
• Familiarity with QUPATH Software

Hiring Salary Range: 

• Postdoctoral Research Scientist: $68,000 - $72,000

Columbia University is an Equal Opportunity Employer / Disability / Veteran

Pay Transparency Disclosure

The salary of the finalist selected for this role will be set based on a variety of factors, including but not limited to departmental budgets, qualifications, experience, education, licenses, specialty, and training.  The above hiring range represents the University's good faith and reasonable estimate of the range of possible compensation at the time of posting.

About Columbia University

Columbia University is one of the world's most important centers of research and at the same time a distinctive and distinguished learning environment for undergraduates and graduate students in many scholarly and professional fields. The University recognizes the importance of its location in New York City and seeks to link its research and teaching to the vast resources of a great metropolis. It seeks to attract a diverse and international faculty and student body, to support research and teaching on global issues, and to create academic relationships with many countries and regions. It expects all areas of the university to advance knowledge and learning at the highest level and to convey the products of its efforts to the world.

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